产品说明书

	同义名 :	硫酸头孢匹罗 ;HR-810 sulfate
	CAS号 :	98753-19-6
	货号 :	A215674
	分子式 :	C22H24N6O9S3
	纯度 :	98%
	分子量 :	612.656
	MDL号 :	MFCD08234364
	存储条件：	粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Cefpirome Sulfate (CPR) is an injectable extended-spectrum or 'fourth generation' cephalosporin. Its antibacterial activity encompasses many of the pathogens involved in hospital-acquired infections such as enterobacteriaceae, methicillin-susceptible staphylococcus aureus, coagulase-negative staphylococci and viridans group streptococci. The tolerability of cefpirome appears similar to that of ceftazidime and other third generation cephalosporins, diarrhoea being the most frequently observed event[3]. Cefpirome sulfate caused strong quenching of the fluorescence of lysozyme by a static quenching mechanism[4]. When cefpirome sulfate was injected intracutaneously at a high concentration of 20%, its irritating effects were only equal to or slightly stronger than those of distilled water for injection and Na2SO4 solution[5].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	1.63mL 0.33mL 0.16mL	8.16mL 1.63mL 0.82mL	16.32mL 3.26mL 1.63mL

参考文献

[1]Kobayashi S, Arai S, et al. Beta-lactamase stability of cefpirome (HR 810), a new cephalosporin with a broad antimicrobial spectrum. Antimicrob Agents Chemother. 1986 Nov;30(5):713-8. [2]Wise R, Andrews JM, et al. The antimicrobial activity of cefpirome, a new cephalosporin. J Antimicrob Chemother. 1985 Apr;15(4):449-56. [3]Wiseman LR, Lamb HM. Cefpirome. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy in the treatment of severe nosocomial infections and febrile neutropenia. Drugs. 1997;54(1):117–140 [4]Han R, Liu B, Li G, Zhang Q. Investigation on the interaction of cefpirome sulfate with lysozyme by fluorescence quenching spectroscopy and synchronous fluorescence spectroscopy. Luminescence. 2016;31(2):580–586 [5]Satoh R, Yajima R, Morioka H, et al. J Toxicol Sci. 1990;15 Suppl 3:147–171