Cefaclor is an orally active cephalosporin antibiotic that is well absorbed. It specifically targets penicillin-binding protein 3 (PBP3) and is used for the treatment and research of various bacterial infections such as respiratory tract infections, bacterial bronchitis, pharyngitis, and skin infections. It also has potential implications for studying depression[1].[2].[3].[4].
体内研究
When administered orally at a dosage of 200 mg/kg/day for five consecutive days, Cefaclor can disturb the intestinal flora balance in mice, leading to anxiety and depression-like behaviors. These effects are alleviated with treatments like Fluoxetine or vagotomy[1].
体外研究
In laboratory tests, Cefaclor demonstrates significant antibacterial activity against 556 Gram-positive and Gram-negative bacterial isolates. It typically exhibits low minimum inhibitory concentrations (MIC), with most strains showing MIC values below 3.1 μg/mL, and specifically, Staphylococcus aureus has an MIC of 1 μg/mL[4].
Cefaclor is primarily transported by hPepT2 and hPepT1 transporters in an MDCK cell line stably transduced to overexpress hOAT1, hPepT1, and hPepT2. This interaction was observed at concentrations of 60/500 μM over a period of 30 minutes[2].
At a concentration of 0.16 mg/mL over 30 minutes, Cefaclor can induce allergic reactions by directly activating basophils and mast cells[3].
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