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Carbenicillin disodium {[allProObj[0].p_purity_real_show]}

货号:A202423 同义名: 羧苄青霉素钠 / Sodium carbenicillin; Carbenicillin(sodium salt)

Carbenicillin disodium是一种青霉素衍生物类抗生素,通过抑制革兰氏阴性和阳性细菌的细胞壁合成发挥作用。Carbenicillin disodium可有效替代氨苄青霉素以减少卫星菌落形成,并广泛用于植物转化实验中。

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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
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Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Carbenicillin disodium 化学结构 CAS号:4800-94-6
Carbenicillin disodium 化学结构
CAS号:4800-94-6
Carbenicillin disodium 3D分子结构
CAS号:4800-94-6
Carbenicillin disodium 化学结构 CAS号:4800-94-6
Carbenicillin disodium 3D分子结构 CAS号:4800-94-6
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Carbenicillin disodium 纯度/质量文件 产品仅供科研

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Carbenicillin disodium 生物活性

描述 Carbenicillin disodium is a beta-lactam penicillin derivative that interference with final stage of bacterial cell wall synthesis. Particulate matter from carbenicillin disodium may not be toxic to human macrophages in vitro for up to six days[2]. Carbenicillin (and ticarcillin) for the present would seem better reserved for P. aeruginosa infections[3]. At pH 5, the reduced action of esterase and the increased absorption rate after 3 hr resulted in 50 and 60% absorption of carbenicillin phenyl sodium and carbenicillin indanyl sodium, respectively[4]. Moreover, if the combination of carbenicillin and gentamicin is used in patients with severe renal failure, the dose of carbenicillin should be reduced to prevent rapid inactivation of gentamicin[5].

Carbenicillin disodium 参考文献

[1]Moller NE, Ahlstedt S, et al. Allergological examination of cystic fibrosis patients with skin reactions during carbenicillin treatment. Allergy. 1980 Mar;35(2):135-8.

[2]Tabaka MS, Bollinger RO, McClain PR, Ottenbreit M. Effects of particulate matter from carbenicillin disodium solution on human macrophages in vitro. Am J Hosp Pharm. 1981;38(10):1503–1507

[3]Maki DG, Kurzynski TA, Agger WA. Carbenicillin for treatment of Bacteroides fragilis infections: why not penicillin G?. J Infect Dis. 1978;138(6):859–864

[4]Tsuji A, Miyamoto E, Terasaki T, Yamana T. Carbenicillin prodrugs: kinetics of intestinal absorption competing degradation of the alpha-esters of carbenicillin and prediction of prodrug absorbability from quantitative structure-absorption rate relationship. J Pharm Sci. 1982;71(4):403–406

[5]Weibert RT, Keane WF. Carbenicillin-gentamicin interaction in acute renal failure. Am J Hosp Pharm. 1977;34(10):1137–1139

Carbenicillin disodium 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.37mL

0.47mL

0.24mL

11.84mL

2.37mL

1.18mL

23.68mL

4.74mL

2.37mL

Carbenicillin disodium 技术信息

CAS号4800-94-6
分子式C17H16N2Na2O6S
分子量 422.36
SMILES Code O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(C(C([O-])=O)C3=CC=CC=C3)=O)N1C2=O)[O-].[Na+].[Na+]
MDL No. MFCD00077683
别名 羧苄青霉素钠 ;Sodium carbenicillin; Carbenicillin(sodium salt); NSC 111071; CP 15,639-2; α-Carboxybenzylpenicillin; BRL 2064
运输蓝冰
InChI Key RTYJTGSCYUUYAL-YCAHSCEMSA-L
Pubchem ID 20933
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere, 2-8°C

溶解方案

DMSO: 60 mg/mL(142.06 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 120 mg/mL(284.12 mM),配合低频超声助溶

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