Carbenicillin disodium

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Chemical Structure| 4800-94-6 同义名 : 羧苄青霉素钠 ;Sodium carbenicillin; Carbenicillin(sodium salt); NSC 111071; CP 15,639-2; α-Carboxybenzylpenicillin; BRL 2064
CAS号 : 4800-94-6
货号 : A202423
分子式 : C17H16N2Na2O6S
纯度 : ≥770 μg/mg
分子量 : 422.363
MDL号 : MFCD00077683
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(142.06 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 120 mg/mL(284.12 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Carbenicillin disodium is a beta-lactam penicillin derivative that interference with final stage of bacterial cell wall synthesis. Particulate matter from carbenicillin disodium may not be toxic to human macrophages in vitro for up to six days[2]. Carbenicillin (and ticarcillin) for the present would seem better reserved for P. aeruginosa infections[3]. At pH 5, the reduced action of esterase and the increased absorption rate after 3 hr resulted in 50 and 60% absorption of carbenicillin phenyl sodium and carbenicillin indanyl sodium, respectively[4]. Moreover, if the combination of carbenicillin and gentamicin is used in patients with severe renal failure, the dose of carbenicillin should be reduced to prevent rapid inactivation of gentamicin[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.37mL

0.47mL

0.24mL

11.84mL

2.37mL

1.18mL

23.68mL

4.74mL

2.37mL
参考文献

[1]Moller NE, Ahlstedt S, et al. Allergological examination of cystic fibrosis patients with skin reactions during carbenicillin treatment. Allergy. 1980 Mar;35(2):135-8.

[2]Tabaka MS, Bollinger RO, McClain PR, Ottenbreit M. Effects of particulate matter from carbenicillin disodium solution on human macrophages in vitro. Am J Hosp Pharm. 1981;38(10):1503–1507

[3]Maki DG, Kurzynski TA, Agger WA. Carbenicillin for treatment of Bacteroides fragilis infections: why not penicillin G?. J Infect Dis. 1978;138(6):859–864

[4]Tsuji A, Miyamoto E, Terasaki T, Yamana T. Carbenicillin prodrugs: kinetics of intestinal absorption competing degradation of the alpha-esters of carbenicillin and prediction of prodrug absorbability from quantitative structure-absorption rate relationship. J Pharm Sci. 1982;71(4):403–406

[5]Weibert RT, Keane WF. Carbenicillin-gentamicin interaction in acute renal failure. Am J Hosp Pharm. 1977;34(10):1137–1139