货号:A605340 同义名: AR-C69931MX tetrasodium;Cangrelor (sodium salt)
Cangrelor is a potent and competitive P2Y12 receptor inhibitor that inhibits of ADP-induced platelet aggregation.
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描述 | Cangrelor is the only currently available intravenous platelet P2Y12 receptor inhibitor, and its quick onset and offset make it an appealing option for antiplatelet therapy[1]. In vitro, the experiment focused on αIIbβ3 complex (platelet receptor for fibrinogen), and cangrelor (140μM, 15 min) suppressed the expression of this surface membrane activation marker in platelets[2]. Cangrelor tetrasodium (10 mg/kg) not only significantly decreases BLM-induced release of inflammatory cytokines (PF4, CD40 L and MPO), but also decreases the increment of platelets, neutrophils and platelet-neutrophil aggregates in the fibrotic lung and in the peripheral blood of BLM-treated mice[3]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT03182855 | Acute Coronary Syndrome ... 展开 >> Myocardial Infarction STEMI - ST Elevation Myocardial Infarction 收起 << | Phase 4 | Not yet recruiting | August 1, 2019 | Denmark ... 展开 >> Aarhus University Hospital Not yet recruiting Aarhus, Denmark, 8200 Contact: Jacob Thorsted Sorensen, MD, PhD +4540143563 jacsoe@rm.dk Contact: Steen D Kristensen, MD, DMSc +4530922336 stekrist@rm.dk 收起 << |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
1.16mL 0.23mL 0.12mL |
5.79mL 1.16mL 0.58mL |
11.57mL 2.31mL 1.16mL |
CAS号 | 163706-36-3 |
分子式 | C17H21Cl2F3N5Na4O12P3S2 |
分子量 | 864.287 |
别名 | AR-C69931MX tetrasodium;Cangrelor (sodium salt);AR-C69931MX |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Inert atmosphere,2-8°C |
溶解度 |
DMSO: 12 mg/mL(13.88 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 120 mg/mL(138.84 mM),配合低频超声助溶 |
动物实验配方 |