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首页 / 药物研究 / 药剂学相关 / 助溶剂 / CHAPS

[3-[4-(胆酰胺丙基)二甲氨基]丙磺酸内盐] /CHAPS {[allProObj[0].p_purity_real_show]}

货号：A137186

CHAPS（ 3-[3-(胆酰胺丙基)二甲氨基]丙磺酸内盐）是一种两性离子型表面活性剂，其作为一种助溶剂，具有良好的蛋白质溶解和稳定作用。CHAPS 主要用于蛋白质分离、膜蛋白研究和蛋白质复合物的制备。

CHAPS 化学结构 CAS号：75621-03-3
CHAPS 化学结构
CAS号：75621-03-3
CHAPS 3D分子结构
CAS号：75621-03-3
CHAPS 化学结构 CAS号：75621-03-3
CHAPS 3D分子结构 CAS号：75621-03-3
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CHAPS 纯度/质量文件 产品仅供科研

货号：A137186 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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• Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]
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• BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]
• J. Am. Soc. Mass Spectrom., 2024, 35(12): 3192-3202. Ambeed. [ A166127 , A902473 , A753371 , A961334 , A292945 , A230770 , A300620 , A1114580 , A1159765 , A206238 ]
• PloS One, 2024, 19(11): e0308060. Ambeed. [ A302917 ]
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CHAPS 生物活性

描述 CHAPS is a non denaturing zwitterionic detergent for membrane biochemistry. It can be used to dissolve membrane proteins and interrupt protein-protein interactions. The zwitterionic detergent CHAPS, a derivative of the bile salts, is widely used in membrane protein solubilization. CHAPS has a low affinity for the erythrocyte membrane (partition coefficient K=0.06mM(-1)), and at sub-hemolytic concentrations it causes little effect on membrane lipid order. CHAPS hemolysis and phospholipid solubilization are closely correlated[1]. Chemical cross-linking shows that the dimerization of EnvZ-PD is significantly inhibited by the CHAPS and cholate[2]. The recovery and preservation of catalytic activity of two trans-membrane proteases, dipeptidyl peptidase IV and nephrilysin, was examined and found to be clearly superior after CHAPS treatment compared to DTT(dithiothreitol). Proteomic profiling by mass spectrometry (MS) revealed that 76.2% of proteins recovered by CHAPS are common to those seen for DTT treatment, which illustrates underlining similarities between the two approaches[3].

CHAPS 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03241810 Metastatic Breast Cancer Phase 2 Recruiting September 2020 -
NCT03056755 Breast Cancer Phase 2 Recruiting April 10, 2020 -
NCT03155997 Breast Cancer Phase 3 Recruiting June 10, 2027 -

CHAPS 参考文献

[1]Rodi PM, Bocco Gianello MD, Corregido MC, Gennaro AM. Comparative study of the interaction of CHAPS and Triton X-100 with the erythrocyte membrane. Biochim Biophys Acta. 2014 Mar;1838(3):859-66.

[2]Hwang E, Cheong HK, Kim SY, Kwon O, Blain KY, Choe S, Yeo KJ, Jung YW, Jeon YH, Cheong C. Crystal structure of the EnvZ periplasmic domain with CHAPS. FEBS Lett. 2017 May;591(10):1419-1428.

[3]Musante L, Saraswat M, Duriez E, Byrne B, Ravidà A, Domon B, Holthofer H. Biochemical and physical characterisation of urinary nanovesicles following CHAPS treatment. PLoS One. 2012;7(7):e37279.

CHAPS 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.63mL

0.33mL

0.16mL

8.13mL

1.63mL

0.81mL

16.26mL

3.25mL

1.63mL

CHAPS 技术信息

CAS号75621-03-3
分子式C32H58N2O7S
分子量 614.88
别名
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature
溶解度

H2O: 85 mg/mL(138.24 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方

Tags: CHAPS | AmBeed-信号通路专用抑制剂 | CHAPS 纯度/质量文件 | CHAPS 生物活性 | CHAPS 临床数据 | CHAPS 参考文献 | CHAPS 实验方案 | CHAPS 技术信息

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