CHAPS( 3-[3-(胆酰胺丙基)二甲氨基]丙磺酸内盐)是一种两性离子型表面活性剂,其作为一种助溶剂,具有良好的蛋白质溶解和稳定作用。CHAPS 主要用于蛋白质分离、膜蛋白研究和蛋白质复合物的制备。
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描述 | CHAPS is a non denaturing zwitterionic detergent for membrane biochemistry. It can be used to dissolve membrane proteins and interrupt protein-protein interactions. The zwitterionic detergent CHAPS, a derivative of the bile salts, is widely used in membrane protein solubilization. CHAPS has a low affinity for the erythrocyte membrane (partition coefficient K=0.06mM(-1)), and at sub-hemolytic concentrations it causes little effect on membrane lipid order. CHAPS hemolysis and phospholipid solubilization are closely correlated[1]. Chemical cross-linking shows that the dimerization of EnvZ-PD is significantly inhibited by the CHAPS and cholate[2]. The recovery and preservation of catalytic activity of two trans-membrane proteases, dipeptidyl peptidase IV and nephrilysin, was examined and found to be clearly superior after CHAPS treatment compared to DTT(dithiothreitol). Proteomic profiling by mass spectrometry (MS) revealed that 76.2% of proteins recovered by CHAPS are common to those seen for DTT treatment, which illustrates underlining similarities between the two approaches[3]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT03241810 | Metastatic Breast Cancer | Phase 2 | Recruiting | September 2020 | - |
NCT03056755 | Breast Cancer | Phase 2 | Recruiting | April 10, 2020 | - |
NCT03155997 | Breast Cancer | Phase 3 | Recruiting | June 10, 2027 | - |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
1.63mL 0.33mL 0.16mL |
8.13mL 1.63mL 0.81mL |
16.26mL 3.25mL 1.63mL |
CAS号 | 75621-03-3 |
分子式 | C32H58N2O7S |
分子量 | 614.88 |
别名 | |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Inert atmosphere,Room Temperature |
溶解度 |
H2O: 85 mg/mL(138.24 mM),配合低频超声,并水浴加热至45℃助溶 |
动物实验配方 |