There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
CGP37157 is identified as a potent and selective inhibitor of the Na+/Ca2+ exchanger, particularly effective in blocking Na+-induced Ca2+-release from guinea-pig heart mitochondria at an IC50 of 0.8 μM. At a concentration of 10 μM, CGP37157 inhibits the mitochondrial Na+/Ca2+ exchanger in cortical neurons, managing intracellular Ca2+ levels by dampening voltage-gated calcium channels and mitigating NMDA-induced rises in cytosolic and mitochondrial Ca2+. Additionally, CGP37157 at this concentration diminishes NMDA-triggered excitotoxicity through the reduction of mitochondrial damage and calpain activity in neurons[2]. CGP37157 (10 μM) combined with salomycin significantly decreased the viability of FaDu and HLaC79 cells, and increased cell apoptosis. In addition, CGP37157 had no inhibitory effect on the tumor toxicity of salomycin [3].
体外研究
CGP37157 is identified as a potent and selective inhibitor of the Na+/Ca2+ exchanger, particularly effective in blocking Na+-induced Ca2+-release from guinea-pig heart mitochondria at an IC50 of 0.8 μM.
At a concentration of 10 μM, CGP37157 inhibits the mitochondrial Na+/Ca2+ exchanger in cortical neurons, managing intracellular Ca2+ levels by dampening voltage-gated calcium channels and mitigating NMDA-induced rises in cytosolic and mitochondrial Ca2+. Additionally, CGP37157 at this concentration diminishes NMDA-triggered excitotoxicity through the reduction of mitochondrial damage and calpain activity in neurons[2].
CGP37157 (10 μM) combined with salomycin significantly decreased the viability of FaDu and HLaC79 cells, and increased cell apoptosis. In addition, CGP37157 had no inhibitory effect on the tumor toxicity of salomycin [3].
搜索
HazMat Fee +
