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/ Busulfan

白消安 /Busulfan {[allProObj[0].p_purity_real_show]}

货号：A593389 同义名： 1,4-双甲基硫氧基丁烷 / Busulphan;NSC-750

Busulfan is a bifunctional alkylating agent.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
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Busulfan 化学结构 CAS号：55-98-1
Busulfan 化学结构
CAS号：55-98-1
Busulfan 3D分子结构
CAS号：55-98-1
Busulfan 化学结构 CAS号：55-98-1
Busulfan 3D分子结构 CAS号：55-98-1
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Busulfan 纯度/质量文件 产品仅供科研

货号：A593389 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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Busulfan 生物活性

描述 Busulfan (BU), an alkylating agent that causes DNA damage by cross-linking DNAs and DNA and proteins, induces senescence in normal human diploid WI38 fibroblasts through the extracellular signal-regulated kinase (Erk) and p38 mitogen-activated protein kinase (p38 MAPK) cascade independent of the p53-DNA damage pathway[3]. Busulfan (40 mg/kg, i.p) increases apoptosis and decreases the testis weight in mice. The testes of Busulfan-treated mice exhibits higher level of pRB expression, inhibits Rb phosphorylation and PCNA expression compared to the control[4]. Busulfan (2.5, 5.0 mg/kg, i.p.) causes earlier occurrence of persistent esturs in a dose dependent manner in rats. Busulfan (5.0 mg/kg) also increases the incidence of uterine adenocarcinomas and multiplicity of uterine neoplastic lesions. In addition, Busulfan decreases the serum 17β-estradiol(E2), progesterone and inhibin levels in rats, and elevates the E2/progesterone ratio only at 5.0 mg/kg[5]. IV busulfan is a convenient, safe, and effective conditioning agent used in HSCT (hematopoietic stem cell transplantation) that has a predictable pharmacokinetic profile[6].

Busulfan 细胞研究

细胞系 浓度 检测类型 检测时间 活动说明 数据源
Kelly cells 10-100 μM Proliferation assay 72 h Antiproliferative activity against human Kelly cells at 10 to 100 uM after 72 hrs by MTT assay 24814532
LS cells 10-100 μM Proliferation assay 72 h Antiproliferative activity against human LS cells at 10 to 100 uM after 72 hrs by MTT assay 24814532
SiMa cells 10-100 μM Proliferation assay 72 h Antiproliferative activity against human SiMa cells at 10 to 100 uM after 72 hrs by MTT assay 24814532
SK-N-SH cells 10-100 μM Proliferation assay 72 h Antiproliferative activity against human SK-N-SH cells at 10 to 100 uM after 72 hrs by MTT assay 24814532

Busulfan 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02114502 Myeloma Phase 2 Withdrawn - -
NCT00997386 Hematologic Neoplasms ... 展开 >> Multiple Myeloma Anemia, Aplastic Hemoglobinuria, Paroxysmal Myelofibrosis 收起 << Phase 2 Completed - United States, Arizona ... 展开 >> University Medical Center and UMC-North Clinic Tucson, Arizona, United States, 85719 收起 <<
NCT01471444 Disorder Related to Bone Marro... 展开 >>w Transplantation Leukemia Transplantation Infection 收起 << Phase 3 Active, not recruiting November 1, 2020 United States, Texas ... 展开 >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 收起 <<

Busulfan 参考文献

[1]Probin V, Wang Y, et al. Busulfan-induced senescence is dependent on ROS production upstream of the MAPK pathway. Free Radic Biol Med. 2007 Jun 15;42(12):1858-65. Epub 2007 Mar 31.

[2]Meng A, Wang Y, et al. Ionizing radiation and busulfan induce premature senescence in murine bone marrow hematopoietic cells. Cancer Res. 2003 Sep 1;63(17):5414-9.

[3]Probin V, Wang Y, Zhou D. Busulfan-induced senescence is dependent on ROS production upstream of the MAPK pathway. Free Radic Biol Med. 2007 Jun 15;42(12):1858-65

[4]Choi YJ, Ok DW, Kwon DN, Chung JI, Kim HC, Yeo SM, Kim T, Seo HG, Kim JH. Murine male germ cell apoptosis induced by busulfan treatment correlates with loss of c-kit-expression in a Fas/FasL- and p53-independent manner. FEBS Lett. 2004 Sep 24;575(1-3):41-51

[5]Yoshida M, Watanabe G, Shirota M, Maekawa A, Taya K. Reduction of primordial follicles caused by maternal treatment with busulfan promotes endometrial adenocarcinoma development in donryu rats. J Reprod Dev. 2005 Dec;51(6):707-14

[6]Fisher VL, Barnes YJ, Nuss SL. Pretransplant conditioning in adults and children: dose assurance with intravenous busulfan. Oncol Nurs Forum. 2006 Nov 3;33(2):E36-43

Busulfan 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.06mL

0.81mL

0.41mL

20.30mL

4.06mL

2.03mL

40.60mL

8.12mL

4.06mL

Busulfan 技术信息

CAS号55-98-1
分子式C6H14O6S2
分子量 246.302
别名 1,4-双甲基硫氧基丁烷 ;Busulphan;NSC-750;14di(methylsulfonyloxy)butane.;14di(methanesulfonyloxy)butane;14butanediol dimethylsulfonate;14bitanediol dimethanesulfonate esters;14bis(methanesulfonoxy)butane;Chemical structure names: ;WR19508;GT41;Code names: CB2041;BUS;Abbreviations: BU;Misulfan;Misulban;Sulfabutin;Myelosan;Myeleukon;methanesulfonic acid tetramethylene ester;glyzophrol;Busulfanum;Bussulfam;NCI C01592;Myleran;Mylecytan;Myeloleukon;Milecitan;Mielosan
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature
溶解度

DMSO: 50 mg/mL(203 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

IP 2% DMSO+2% Tween80+40% PEG300+water 10 mg/mL clear

PO 0.5% CMC-Na 44 mg/mL suspension

Tags: Busulfan | Busulphan;NSC-750;14di(methylsulfonyloxy)butane.;14di(methanesulfonyloxy)butane;14butanediol dimethylsulfonate;14bitanediol dimethanesulfonate esters;14bis(methanesulfonoxy)butane;Chemical structure names: ;WR19508;GT41;Code names: CB2041;BUS;Abbreviations: BU;Misulfan;Misulban;Sulfabutin;Myelosan;Myeleukon;methanesulfonic acid tetramethylene ester;glyzophrol;Busulfanum;Bussulfam;NCI C01592;Myleran;Mylecytan;Myeloleukon;Milecitan;Mielosan | 1,4-双甲基硫氧基丁烷 | DNA Alkylator/Crosslinker | AmBeed-信号通路专用抑制剂 | Busulfan 纯度/质量文件 | Busulfan 生物活性 | Busulfan 细胞研究 | Busulfan 临床数据 | Busulfan 参考文献 | Busulfan 实验方案 | Busulfan 技术信息

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