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/ Benznidazole

苄硝唑 /Benznidazole {[allProObj[0].p_purity_real_show]}

货号：A398551 同义名： Ro 71051;Ro 07-1051

Benznidazole是一种抗寄生虫药物，对哥伦比亚 T. cruzi 菌株的 IC50 值为 20.35 μM。

Benznidazole 化学结构 CAS号：22994-85-0
Benznidazole 化学结构
CAS号：22994-85-0
Benznidazole 3D分子结构
CAS号：22994-85-0
Benznidazole 化学结构 CAS号：22994-85-0
Benznidazole 3D分子结构 CAS号：22994-85-0
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Benznidazole 纯度/质量文件 产品仅供科研

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Benznidazole 生物活性

描述 Benznidazole is recommended for treatment of Chagas infection. Benznidazole monotherapy is superior to posaconazole, with high RT-PCR (real time polymerase chain reaction) conversion rates sustained at 1 year. Side effects lead to therapy discontinuation in 32%. No advantages were observed with combined therapy versus benznidazole monotherapy[3]. Benznidazole shows high bioavailability after oral administration. Benznidazole at 5 - 8 mg/kg/day and 5 - 10 mg/kg/day for 30 - 60 days are consistent clinical recommendations for children and adults, respectively[4]. The trypanocidal activity of vitamin C and benznidazole was similar for the three parasite forms. Animals treated with benznidazole presented lower parasitemia levels, as compared with those treated with vitamin C alone. Again, vitamin C did not cause any effect on the antiparasitic profile of benznidazole. The combination of vitamin C with benznidazole could be considered as an alternative treatment for Chagas' disease[5]. Patients previously treated with benznidazole had significantly reduced parasitemia, a lower prevalence of markers of severe cardiomyopathy, and lower mortality after two years of follow-up. If used in the early phases, benznidazole treatment may improve clinical and parasitological outcomes in patients with chronic ChD (chronic Chagas disease)[6].

Benznidazole 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02625974 Chagas Disease Phase 3 Active, not recruiting August 9, 2021 Argentina ... 展开 >> La Plata, Buenos Aires, Argentina, 1900 Buenos Aires, Ciudad Auton. De Buenos Aires, Argentina, 1281 Buenos Aires, Ciudad Auton. De Buenos Aires, Argentina, C1270AAN Buenos Aires, Ciudad Auton. De Buenos Aires, Argentina, C1425AGP Buenos Aires, Ciudad Auton. De Buenos Aires, Argentina, C1425EFD San Salvador de Jujuy, Jujuy, Argentina, 4600 Posadas, Misiones, Argentina Rosario, Santa Fe, Argentina, 2000 Corrientes, Argentina, W3400CBI Formosa, Argentina, P3600HZL La Rioja, Argentina Mendoza, Argentina, 5500 Mendoza, Argentina, 5535 Salta, Argentina, 4400 Salta, Argentina, A4400ESE San Juan, Argentina, 5400 Santiago del Estero, Argentina, 4202 Tucuman, Argentina, 4000 Bolivia Cochabamba, Bolivia Punata, Bolivia Tarija, Bolivia Colombia Barranquilla, Atlántico, Colombia Yopal, Casanare, Colombia, 0 Santa Marta, Magdalena, Colombia, 0 Floridablanca, Santander, Colombia 收起 <<
NCT01377480 Chagas Disease Phase 2 Completed - -
NCT01377480 - Completed - -

Benznidazole 参考文献

[1]Perin L, Moreira da Silva R, et al. Pharmacokinetics and Tissue Distribution of Benznidazole after Oral Administration in Mice. Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02410-16.

[2]Maranon C, Egui A, et al. Benznidazole treatment reduces the induction of indoleamine 2,3-dioxygenase (IDO) enzymatic activity in Chagas disease symptomatic patients. Parasite Immunol. 2013 May-Jun;35(5-6):180-7.

[3]Morillo CA, Waskin H, Sosa-Estani S, et al. Benznidazole and Posaconazole in Eliminating Parasites in Asymptomatic T. Cruzi Carriers: The STOP-CHAGAS Trial. J Am Coll Cardiol. 2017;69(8):939‐947

[4]Caldas IS, Santos EG, Novaes RD. An evaluation of benznidazole as a Chagas disease therapeutic. Expert Opin Pharmacother. 2019;20(15):1797‐1807

[5]Puente V, Demaria A, Frank FM, Batlle A, Lombardo ME. Anti-parasitic effect of vitamin C alone and in combination with benznidazole against Trypanosoma cruzi. PLoS Negl Trop Dis. 2018;12(9):e0006764. Published 2018 Sep 21

[6]Cardoso CS, Ribeiro ALP, Oliveira CDL, et al. Beneficial effects of benznidazole in Chagas disease: NIH SaMi-Trop cohort study. PLoS Negl Trop Dis. 2018;12(11):e0006814. Published 2018 Nov 1

Benznidazole 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.84mL

0.77mL

0.38mL

19.21mL

3.84mL

1.92mL

38.42mL

7.68mL

3.84mL

Benznidazole 技术信息

CAS号22994-85-0
分子式C12H12N4O3
分子量 260.249
别名 Ro 71051;Ro 07-1051;Rochagan.;NSC 299972;Radanil;Benznidazol
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,Room Temperature
溶解方案

DMSO: 50 mg/mL(192.12 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案一
方案二
动物实验配方

Tags: Benznidazole | Ro 71051;Ro 07-1051;Rochagan.;NSC 299972;Radanil;Benznidazol | Imidazole | Antiparasitic | AmBeed-信号通路专用抑制剂 | Benznidazole 纯度/质量文件 | Benznidazole 生物活性 | Benznidazole 临床数据 | Benznidazole 参考文献 | Benznidazole 实验方案 | Benznidazole 技术信息

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