苯溴马隆 /Benzbromarone
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货号：A218663
同义名：
MJ10061;Desuric
Benzbromarone is a CYP2C9 inhibitor with Ki of 19.3 nM.
Benzbromarone 化学结构
Benzbromarone 3D分子结构
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Benzbromarone 纯度/质量文件 产品仅供科研
货号：A218663
标准纯度：
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Benzbromarone 质控信息
Benzbromarone 生物活性
描述
Benzbromarone is a highly effective and well tolerated non-competitive inhibitor of xanthine oxidase, used as an uricosuric agent, used in the treatment of gout[3] [4] [5] [6] [7]
Benzbromarone 参考文献
[1] Kaufmann P, Torok M, et al. Mechanisms of benzarone and benzbromarone-induced hepatic toxicity. Hepatology. 2005 Apr;41(4):925-35.
[2] Locuson CW 2nd, Wahlstrom JL, et al. A new class of CYP2C9 inhibitors: probing 2C9 specificity with high-affinity benzbromarone derivatives. Drug Metab Dispos. 2003 Jul;31(7):967-71.
[3] LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. Benzbromarone. 2017 Sep 5
[4] Abdel-Razek EA, Abo-Youssef AM, Azouz AA. Benzbromarone mitigates cisplatin nephrotoxicity involving enhanced peroxisome proliferator-activated receptor-alpha (PPAR-α) expression. Life Sci. 2020 Feb 15;243:117272
[5] Sun P, Zhu JJ, Wang T, Huang Q, Zhou YR, Yu BW, Jiang HL, Wang HY. Benzbromarone aggravates hepatic steatosis in obese individuals. Biochim Biophys Acta Mol Basis Dis. 2018 Jun;1864(6 Pt A):2067-2077
[6] Roos NJ, Duthaler U, Bouitbir J, Krähenbühl S. The uricosuric benzbromarone disturbs the mitochondrial redox homeostasis and activates the NRF2 signaling pathway in HepG2 cells. Free Radic Biol Med. 2020 May 20;152:216-226
[7] Muraya N, Kadowaki D, Miyamura S, Kitamura K, Uchimura K, Narita Y, Miyamoto Y, Chuang VTG, Taguchi K, Maruyama T, Otagiri M, Hirata S. Benzbromarone Attenuates Oxidative Stress in Angiotensin II- and Salt-Induced Hypertensive Model Rats. Oxid Med Cell Longev. 2018 Jun 5;2018:7635274
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Benzbromarone 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
2.36mL
0.47mL
0.24mL
11.79mL
2.36mL
1.18mL
23.58mL
4.72mL
2.36mL
Benzbromarone 技术信息
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