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贝那普利 /Benazepril {[allProObj[0].p_purity_real_show]}

货号：A651804 同义名： 贝那普利游离碱 Ambeed 开学季，买赠积分，赢豪礼

Benazepril is an ACE inhibitor, primarily used in treatment of hypertension.

Benazepril 化学结构 CAS号：86541-75-5
Benazepril 化学结构
CAS号：86541-75-5
Benazepril 3D分子结构
CAS号：86541-75-5
Benazepril 化学结构 CAS号：86541-75-5
Benazepril 3D分子结构 CAS号：86541-75-5
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Benazepril 纯度/质量文件 产品仅供科研

货号：A651804 标准纯度： {[allProObj[0].p_purity_real_show]}
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Benazepril 生物活性

靶点

  • ACE
描述 Benazepril, an angiotensin converting enzyme inhibitor, which is a medication used to treat high blood pressure. Benazepril conferred substantial renal benefits in patients without diabetes who had advanced renal insufficiency[3]. When the similar SBP (Systolic blood pressure) reduction, RAAS (renin-angiotensin-aldosterone system) inhibition and clock gene profile were achieved with optimal dose of benazepril, morning versus evening dosing of benazepril has the same renoprotection effects[4]. 0.25-0.5 mg/kg benazepril administered BID produced noninferior inhibition of serum ACE activity compared to 0.5-1.0 mg/kg benazepril dosed SID[5]. The combination use of leflunomide and benazepril could improve the renal function and reduce the renal injury of DN (diabetic nephropathy) rats and could reduce the levels of NF-κb, TGF-β and TRPC6 in both DN rats and high-glucose induced RMCs (rat glomerular mesangial cells)[6].

Benazepril 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00000620 Atherosclerosis ... 展开 >> Cardiovascular Diseases Hypercholesterolemia Hypertension Diabetes Mellitus, Type 2 Diabetes Mellitus Coronary Disease 收起 << Phase 3 Completed - United States, Minnesota ... 展开 >> Minneapolis Medical Research Foundation Minneapolis, Minnesota, United States, 55404 United States, New York Columbia University New York, New York, United States, 10027 United States, North Carolina Wake Forest University Winston-Salem, North Carolina, United States, 27106 United States, Ohio Case Western Reserve University Cleveland, Ohio, United States, 44106 United States, Tennessee Veterans Affairs Memphis, Tennessee, United States, 38104 United States, Washington University of Washington Seattle, Washington, United States, 98195 Canada, Ontario McMaster University Hamilton, Ontario, Canada 收起 <<
NCT00000620 - Completed - -
NCT01076205 - Completed - -

Benazepril 参考文献

[1]Huang XM, Yuan JP, et al. Effects of chronotherapy of benazepril on the diurnal profile of RAAS and clock genes in the kidney of 5/6 nephrectomy rats. J Huazhong Univ Sci Technolog Med Sci. 2013 Jun;33(3):368-74.

[2]Hou FF, Zhang X, et al. Efficacy and safety of benazepril for advanced chronic renal insufficiency. N Engl J Med. 2006 Jan 12;354(2):131-40.

[3]Hou FF, Zhang X, Zhang GH, Xie D, Chen PY, Zhang WR, Jiang JP, Liang M, Wang GB, Liu ZR, Geng RW. Efficacy and safety of benazepril for advanced chronic renal insufficiency. N Engl J Med. 2006 Jan 12;354(2):131-40

[4]Huang XM, Yuan JP, Zeng XR, Peng CX, Mei QH, Chen WL. Effects of chronotherapy of benazepril on the diurnal profile of RAAS and clock genes in the kidney of 5/6 nephrectomy rats. J Huazhong Univ Sci Technolog Med Sci. 2013 Jun;33(3):368-374

[5]King JN, Christinaz C, Strehlau G, Hornfeld J. Effect of benazepril and pimobendan on serum angiotensin-converting enzyme activity in dogs. J Vet Pharmacol Ther. 2018 Jun;41(3):485-489

[6]Li H, Wang Y, Zhou Z, Tian F, Yang H, Yan J. Combination of leflunomide and benazepril reduces renal injury of diabetic nephropathy rats and inhibits high-glucose induced cell apoptosis through regulation of NF-κB, TGF-β and TRPC6. Ren Fail. 2019 Nov;41(1):899-906

Benazepril 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.36mL

0.47mL

0.24mL

11.78mL

2.36mL

1.18mL

23.56mL

4.71mL

2.36mL

Benazepril 技术信息

CAS号86541-75-5
分子式C24H28N2O5
分子量 424.49
别名 贝那普利游离碱
运输蓝冰
存储条件

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 105 mg/mL(247.36 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Benazepril | 86541-75-5 | ACE Inhibitor | Metabolic Enzyme/Protease | Angiotensin-converting Enzyme (ACE) | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Benazepril 纯度/质量文件 | Benazepril 生物活性 | Benazepril 临床数据 | Benazepril 参考文献 | Benazepril 实验方案 | Benazepril 技术信息

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