There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Bemnifosbuvir (AT-511) is a potent orally active HCV viral replication inhibitor effective against SARS-CoV-2 (COVID-19) infection in vitro (EC90=0.47 μM), exhibiting pangenotypic antiviral activity [1][2][3].
体内研究
Orally administered to rats (500 mg/kg) and monkeys (30 mg/kg, 100 mg/kg, or 300 mg/kg), Bemnifosbuvir preferentially delivers high levels of AT-9010 in the liverin vivo[1].
In normal human airway epithelial cells, the concentration of Bemnifosbuvir required to inhibit replication of SARS-CoV-2 by EC90 is 0.47 μM, similar to its EC90 against HCoV-229E, HCoV-OC43, and SARS-CoV in Huh-7 cells [2].
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