Ambeed.cn

首页 / 抑制剂/激动剂 / 其他抑制剂/激动剂 / / BC-DXI-843

BC-DXI-843 {[allProObj[0].p_purity_real_show]}

货号:A1275415 Ambeed 开学季,买赠积分,赢豪礼

BC-DXI-843 is an AIMP2-DX2 inhibitor with IC50 value of 0.92μM. It demonstrated in vivo efficacy in a tumor xenograft mouse model (H460 cells) at a dosage of 50 mg/kg.

BC-DXI-843 化学结构 CAS号:2421117-98-6
BC-DXI-843 化学结构
CAS号:2421117-98-6
BC-DXI-843 3D分子结构
CAS号:2421117-98-6
BC-DXI-843 化学结构 CAS号:2421117-98-6
BC-DXI-843 3D分子结构 CAS号:2421117-98-6
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb_sale, 1,1) ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]}
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} 现货 咨询 - +
购物车0 收藏 询单

BC-DXI-843 纯度/质量文件 产品仅供科研

货号:A1275415 标准纯度: {[allProObj[0].p_purity_real_show]}
批次查询: 批次纯度:

全球学术期刊中引用的产品

JACS Au, 2024. Ambeed. [ A148168 ]
JMC, 2024. Ambeed. [ A187643 ]
JMC, 2024. Ambeed. [ A341145 , A633512 , A607865 , A167774 ]
Biomacromolecules, 2024. Ambeed. [ A110759 ]
Biomacromolecules, 2024. Ambeed. [ A203543 ]
更多 >

BC-DXI-843 生物活性

描述 AIMP2-DX2, a splicing variant of AIMP2, is up-regulated in lung cancer, possesses oncogenic activity, and results in tumorigenesis. BC-DXI-843 is a potent and selective AIMP2-DX2 inhibitor with an IC50 value of 0.92 μM which is more than 100-fold selectivity over AIMP2 (IC50 >100 μM) in a luciferase assay. In H460 cells, BC-DXI-843 exhibited dose-dependent inhibition of DX2 protein levels, and it efficiently induced degradation of DX2 at a very low concentration of 1.20 μM. Moreover, BC-DXI-843 demonstrated in vivo efficacy in a tumor xenograft mouse model (H460 cells) at a dosage of 50 mg/kg, suggesting it as a promising lead for development of novel therapeutics targeting AIMP2-DX2 in lung cancer[1].
作用机制 BC-DXI-843 was positioned very close to L80, T82, F116, T117, and K129 and it forms two hydrogen bonds with the hydrophobic pocket via T82 and D52[1].

BC-DXI-843 参考文献

[1]Sivaraman A, Kim DG, Bhattarai D, et al. Synthesis and Structure-Activity Relationships of Arylsulfonamides as AIMP2-DX2 Inhibitors for the Development of a Novel Anticancer Therapy. J Med Chem. 2020;63(10):5139-5158

BC-DXI-843 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.83mL

0.37mL

0.18mL

9.15mL

1.83mL

0.91mL

18.29mL

3.66mL

1.83mL

BC-DXI-843 技术信息

CAS号2421117-98-6
分子式C28H26N4O4S2
分子量 546.66
别名
运输蓝冰
存储条件

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 250 mg/mL(457.32 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
Ambeed 相关网站 Ambeed.cn Ambeed.com
Ambeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
  • 客户支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    Ambeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务,不为任何个人或者非科研性质用途提供服务。