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/ Azithromycin hydrate

阿奇霉素二水合物 /Azithromycin hydrate {[allProObj[0].p_purity_real_show]}

货号：A385826 同义名： 阿奇霉素二水合物 / CP-62993 dihydrate;Azithromycin Dihydrate

Azithromycin hydrate是一种抗生素，能够抑制寄生虫的生长，IC50 为 8.4 μM。

Azithromycin hydrate 化学结构 CAS号：117772-70-0
Azithromycin hydrate 化学结构
CAS号：117772-70-0
Azithromycin hydrate 3D分子结构
CAS号：117772-70-0
Azithromycin hydrate 化学结构 CAS号：117772-70-0
Azithromycin hydrate 3D分子结构 CAS号：117772-70-0
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Azithromycin hydrate 纯度/质量文件 产品仅供科研

货号：A385826 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Neuron, 2025. Ambeed. [ A1440350 ]
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• PLoS Biol., 2025, 23(2): e3002961. Ambeed. [ A181909 ]
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Azithromycin hydrate 生物活性

描述 Azithromycin (Dihydrate) is an azalide, a subclass of macrolide antibiotics. It prevents bacteria from growing by interfering with their protein synthesis. It binds to the 50S subunit of the bacterial ribosome and thus inhibits translation of mRNA. Azithromycin is used to treat or prevent certain bacterial infections, most often those causing middle ear infections, strep throat, pneumonia, typhoid, bronchitis, and sinusitis[3]. Azithromycin dose-dependently augmented viral-induced IFNβ (interferons, IFNs) expression in asthmatic, but not in healthy bronchial epithelial cells. Clinically relevant concentrations of azithromycin produce MDA5-dependent, anti-viral, IFN-inducing effects in bronchial epithelium distinctly from asthmatic donors[4]. Azithromycin treatment induced a perturbation in the gut microbiota 14 days after randomization but did not have long-lasting effects on the gut microbiota composition[5].

Azithromycin hydrate 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00694694 Malaria Phase 3 Completed - Tanzania ... 展开 >> Teule Hospital Muheza, Tanga Region, Tanzania 收起 <<
NCT01235546 Endometritis ... 展开 >>Wound Infection Abscess Surgical Site Infection 收起 << Not Applicable Completed - United States, Alabama ... 展开 >> University of Alabama at Birmingham Birmingham, Alabama, United States, 35233 United States, Louisiana Ochsner Clinic Foundation New Orleans, Louisiana, United States, 70121 United States, Mississippi University of Mississippi Medical Center Jackson, Mississippi, United States, 39216 United States, New York Columbia University New York, New York, United States, 10032 United States, North Carolina Mission Hospital Asheville, North Carolina, United States, 28801 University of North Carolina Chapel Hill, North Carolina, United States, 27599-7516 United States, Texas University of Texas Medical Branch Galveston, Texas, United States, 77555-0587 University of Texas Health Science Center at Houston Houston, Texas, United States, 77225 United States, Utah University of Utah Salt Lake City, Utah, United States, 84132 收起 <<
NCT02527005 Malaria Pregn... 展开 >>ant HIV 收起 << Phase 1 Completed - Nigeria ... 展开 >> University College Hospital, Ibadan, Oyo, Nigeria, 200001 收起 <<

Azithromycin hydrate 参考文献

[1]Menzel M, Akbarshahi H, et al. Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation. Oncotarget. 2017 May 9;8(19):31601-31611.

[2]Vandooren J, Knoops S, et al. Differential inhibition of activity, activation and gene expression of MMP-9 in THP-1 cells by azithromycin and minocycline versus bortezomib: A comparative study. PLoS One. 2017 Apr 3;12(4):e0174853.

[3]Bakheit AH, Al-Hadiya BM, Abd-Elgalil AA. Azithromycin. Profiles Drug Subst Excip Relat Methodol. 2014;39:1‐40

[4]Menzel M, Akbarshahi H, Tufvesson E, Persson C, Bjermer L, Uller L. Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation. Oncotarget. 2017;8(19):31601‐31611

[5]Wei S, Mortensen MS, Stokholm J, et al. Short- and long-term impacts of azithromycin treatment on the gut microbiota in children: A double-blind, randomized, placebo-controlled trial. EBioMedicine. 2018;38:265‐272

Azithromycin hydrate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.27mL

0.25mL

0.13mL

6.37mL

1.27mL

0.64mL

12.74mL

2.55mL

1.27mL

Azithromycin hydrate 技术信息

CAS号117772-70-0
分子式C38H76N2O14
分子量 785.015
别名 阿奇霉素二水合物 ;CP-62993 dihydrate;Azithromycin Dihydrate
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place,Inert atmosphere,Room temperature
溶解方案

DMSO: 105 mg/mL(133.76 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Azithromycin hydrate | CP-62993 dihydrate;Azithromycin Dihydrate | 阿奇霉素二水合物 | Drug Standard | Macrolide | Antiparasitic | AmBeed-信号通路专用抑制剂 | Azithromycin hydrate 纯度/质量文件 | Azithromycin hydrate 生物活性 | Azithromycin hydrate 临床数据 | Azithromycin hydrate 参考文献 | Azithromycin hydrate 实验方案 | Azithromycin hydrate 技术信息

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