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壬二酸,杜鹃花酸 /Azelaic acid {[allProObj[0].p_purity_real_show]}

货号:A121847 同义名: 壬二酸 / Nonanedioic acid;NSC 19493

Azelaic acid is an organic compound produced by the ozonolysis of oleic acid, and a component of a number of hair and skin conditioners.

Azelaic acid 化学结构 CAS号:123-99-9
Azelaic acid 化学结构
CAS号:123-99-9
Azelaic acid 3D分子结构
CAS号:123-99-9
Azelaic acid 化学结构 CAS号:123-99-9
Azelaic acid 3D分子结构 CAS号:123-99-9
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Azelaic acid 纯度/质量文件 产品仅供科研

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Azelaic acid 生物活性

描述 Azelaic acid, a nine-carbon dicarboxylic acid, is recognized for its antimicrobial activities against Propionibacterium acnes and Staphylococcus epidermidis, which it achieves by inhibiting microbial cellular protein synthesis. Additionally, it exhibits hypopigmentation effects due to its capacity to scavenge free radicals[1].[2].
体内研究

Azelaic acid formulated into a 15% gel and applied twice daily has proven to be effective for treating individuals with moderate papulopustular conditions[4].

体外研究

Azelaic acid, at a concentration of 0.5 M and applied over a duration ranging from 48 hours to 7 days, demonstrates effective antimicrobial properties[3].

At a higher concentration of 5 M and over a 24-hour period, azelaic acid effectively reduces intracellular levels of Reactive Oxygen Species (ROS) and enhances antioxidant capacity[5].

In cellular studies, azelaic acid at concentrations ranging from 1 to 100 nM over 24 hours significantly reduces the survival ability of B16, HMB2, and SK23 cells in a dose-dependent manner[6].

Azelaic acid 参考文献

[1]Jung HW, et al. Priming in systemic plant immunity. Science. 2009 Apr 3;324(5923):89-91.

[2]Liu RH, et al. Azelaic acid in the treatment of papulopustular rosacea: a systematic review of randomized controlled trials. Arch Dermatol. 2006 Aug;142(8):1047-52.

[3]J P Leeming, et al. The in vitro antimicrobial effect of azelaic acid. Br J Dermatol. 1986 Nov;115(5):551-6.

[4]Harald Gollnick, et al. Azelaic acid 15% gel in the treatment of rosacea.

[5]Dongdong Zhang, et al. Azelaic Acid Exerts Antileukemia Effects against Acute Myeloid Leukemia by Regulating the Prdxs/ROS Signaling Pathway. Oxid Med Cell Longev. 2020 Dec 23:2020:1295984.

[6]L Lemic-Stojcevic, et al. Dongdong Zhang, et al. Effect of azelaic acid on melanoma cells in culture. Exp Dermatol. 1995 Apr;4(2):79-81.

Azelaic acid 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

5.31mL

1.06mL

0.53mL

26.56mL

5.31mL

2.66mL

53.13mL

10.63mL

5.31mL

Azelaic acid 技术信息

CAS号123-99-9
分子式C9H16O4
分子量 188.221
别名 壬二酸 ;Nonanedioic acid;NSC 19493;Anchoic acid;Azelex;Finacea
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Room Temperature

溶解度

DMSO: 105 mg/mL(557.86 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 2 mg/mL(10.63 mM),配合低频超声助溶

动物实验配方
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