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描述 | Azelaic acid, a nine-carbon dicarboxylic acid, is recognized for its antimicrobial activities against Propionibacterium acnes and Staphylococcus epidermidis, which it achieves by inhibiting microbial cellular protein synthesis. Additionally, it exhibits hypopigmentation effects due to its capacity to scavenge free radicals[1].[2]. |
体内研究 | Azelaic acid formulated into a 15% gel and applied twice daily has proven to be effective for treating individuals with moderate papulopustular conditions[4]. |
体外研究 | Azelaic acid, at a concentration of 0.5 M and applied over a duration ranging from 48 hours to 7 days, demonstrates effective antimicrobial properties[3]. At a higher concentration of 5 M and over a 24-hour period, azelaic acid effectively reduces intracellular levels of Reactive Oxygen Species (ROS) and enhances antioxidant capacity[5]. In cellular studies, azelaic acid at concentrations ranging from 1 to 100 nM over 24 hours significantly reduces the survival ability of B16, HMB2, and SK23 cells in a dose-dependent manner[6]. |
[1]Jung HW, et al. Priming in systemic plant immunity. Science. 2009 Apr 3;324(5923):89-91.
[4]Harald Gollnick, et al. Azelaic acid 15% gel in the treatment of rosacea.
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
5.31mL 1.06mL 0.53mL |
26.56mL 5.31mL 2.66mL |
53.13mL 10.63mL 5.31mL |
CAS号 | 123-99-9 |
分子式 | C9H16O4 |
分子量 | 188.221 |
别名 | 壬二酸 ;Nonanedioic acid;NSC 19493;Anchoic acid;Azelex;Finacea |
运输 | 蓝冰 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Sealed in dry,Room Temperature |
溶解方案 |
DMSO: 105 mg/mL(557.86 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 2 mg/mL(10.63 mM),配合低频超声助溶 以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
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动物实验配方 |