货号:A121847 同义名: 壬二酸 / Nonanedioic acid;NSC 19493
Azelaic acid is an organic compound produced by the ozonolysis of oleic acid, and a component of a number of hair and skin conditioners.
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描述 | Azelaic acid, a nine-carbon dicarboxylic acid, is recognized for its antimicrobial activities against Propionibacterium acnes and Staphylococcus epidermidis, which it achieves by inhibiting microbial cellular protein synthesis. Additionally, it exhibits hypopigmentation effects due to its capacity to scavenge free radicals[1].[2]. |
体内研究 | Azelaic acid formulated into a 15% gel and applied twice daily has proven to be effective for treating individuals with moderate papulopustular conditions[4]. |
体外研究 | Azelaic acid, at a concentration of 0.5 M and applied over a duration ranging from 48 hours to 7 days, demonstrates effective antimicrobial properties[3]. At a higher concentration of 5 M and over a 24-hour period, azelaic acid effectively reduces intracellular levels of Reactive Oxygen Species (ROS) and enhances antioxidant capacity[5]. In cellular studies, azelaic acid at concentrations ranging from 1 to 100 nM over 24 hours significantly reduces the survival ability of B16, HMB2, and SK23 cells in a dose-dependent manner[6]. |
[1]Jung HW, et al. Priming in systemic plant immunity. Science. 2009 Apr 3;324(5923):89-91.
[4]Harald Gollnick, et al. Azelaic acid 15% gel in the treatment of rosacea.
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
5.31mL 1.06mL 0.53mL |
26.56mL 5.31mL 2.66mL |
53.13mL 10.63mL 5.31mL |
CAS号 | 123-99-9 |
分子式 | C9H16O4 |
分子量 | 188.221 |
别名 | 壬二酸 ;Nonanedioic acid;NSC 19493;Anchoic acid;Azelex;Finacea |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Sealed in dry,Room Temperature |
溶解度 |
DMSO: 105 mg/mL(557.86 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 2 mg/mL(10.63 mM),配合低频超声助溶 |
动物实验配方 |