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莠去津 /Atrazine {[allProObj[0].p_purity_real_show]}

货号:A121114 同义名: 阿特拉津 / ATR;Chromozin

Atrazine is a triazine herbicide that is effective in controlling a broad range of weeds, it's also an endocrine disruptor that can cause hormone imbalance and affects the endocrine system in humans and animals.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Atrazine 化学结构 CAS号:1912-24-9
Atrazine 化学结构
CAS号:1912-24-9
Atrazine 3D分子结构
CAS号:1912-24-9
Atrazine 化学结构 CAS号:1912-24-9
Atrazine 3D分子结构 CAS号:1912-24-9
规格 价格 会员价 库存 数量
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Atrazine 纯度/质量文件 产品仅供科研

货号:A121114 标准纯度: {[allProObj[0].p_purity_real_show]}
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Atrazine 生物活性

描述 Atrazine is principally used for control of certain annual broadleaf and grass weeds. Atrazine inhibits photophosphorylation but typically does not result in lethality or permanent cell damage in the short term[2]. ATR (Atrazine) exposure, beginning in utero, causes a shortening (demasculinisation) of penis structures and increases the incidence of hypospadias in mice[3]. Atrazine dose-dependently decreased serum testosterone levels of male pups, with a significant difference from the control recorded at a dose of 100 mg/kg. In addition, atrazine significantly increased fetal Leydig cell aggregation at a dose of 100 mg/kg. Atrazine increased fetal Leydig cell number but not Sertoli cell number. In utero exposure to atrazine disrupted rat fetal testis development[4]. Atrazine exposure resulted in mild effects on the ventral prostate, but remarkable alterations on the efferent ductules, including luminal dilation, reduced epithelial height, and disruption of the epithelial homeostasis, which coincides with increased aromatase expression[5]. Atrazine exposure can decrease the expression and activity of DNMTs (DNA methyltransferase), leading to decreased DNA methylation levels[6].

Atrazine 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00342121 - Completed - United States, Iowa ... 展开 >> University of Iowa Iowa City, Iowa, United States, 52242 收起 <<

Atrazine 参考文献

[2]Solomon KR, Giesy JP, LaPoint TW, Giddings JM, Richards RP. Ecological risk assessment of atrazine in North American surface waters. Environ Toxicol Chem. 2013 Jan;32(1):10-1

[3]Govers LC, Harper AP, Finger BJ, Mattiske DM, Pask AJ, Green MP. Atrazine induces penis abnormalities including hypospadias in mice. J Dev Orig Health Dis. 2020 Jun;11(3):246-249

[4]Fang Y, Ni C, Dong Y, Li H, Wu S, Li X, Lv Y, Huang T, Lian Q, Ge RS. In utero Exposure to Atrazine Disrupts Rat Fetal Testis Development. Front Pharmacol. 2018 Nov 28;9:1391

[5]Martins-Santos E, Pimenta CG, Campos PRN, Oliveira AG, Mahecha GAB, Oliveira CA. Atrazine affects the morphophysiology, tissue homeostasis and aromatase expression in the efferent ductules of adult rats with mild alterations in the ventral prostate. Chemosphere. 2018 Feb;193:958-967

[6]Wirbisky-Hershberger SE, Sanchez OF, Horzmann KA, Thanki D, Yuan C, Freeman JL. Atrazine exposure decreases the activity of DNMTs, global DNA methylation levels, and dnmt expression. Food Chem Toxicol. 2017 Nov;109(Pt 1):727-734

Atrazine 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.64mL

0.93mL

0.46mL

23.18mL

4.64mL

2.32mL

46.37mL

9.27mL

4.64mL

Atrazine 技术信息

CAS号1912-24-9
分子式C8H14ClN5
分子量 215.68
别名 阿特拉津 ;ATR;Chromozin;Atazinax;Atred;Atranex;Fenatrol;Gesaprim;Aktikon;Oleogesaprim
运输蓝冰
存储条件

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 85 mg/mL(394.1 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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