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Atrazine

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Chemical Structure| 1912-24-9 同义名 : 阿特拉津 ;ATR;Chromozin;Atazinax;Atred;Atranex;Fenatrol;Gesaprim;Aktikon;Oleogesaprim
CAS号 : 1912-24-9
货号 : A121114
分子式 : C8H14ClN5
纯度 : 98%
分子量 : 215.68
MDL号 : MFCD00041810
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 85 mg/mL(394.1 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Atrazine is principally used for control of certain annual broadleaf and grass weeds. Atrazine inhibits photophosphorylation but typically does not result in lethality or permanent cell damage in the short term[2]. ATR (Atrazine) exposure, beginning in utero, causes a shortening (demasculinisation) of penis structures and increases the incidence of hypospadias in mice[3]. Atrazine dose-dependently decreased serum testosterone levels of male pups, with a significant difference from the control recorded at a dose of 100 mg/kg. In addition, atrazine significantly increased fetal Leydig cell aggregation at a dose of 100 mg/kg. Atrazine increased fetal Leydig cell number but not Sertoli cell number. In utero exposure to atrazine disrupted rat fetal testis development[4]. Atrazine exposure resulted in mild effects on the ventral prostate, but remarkable alterations on the efferent ductules, including luminal dilation, reduced epithelial height, and disruption of the epithelial homeostasis, which coincides with increased aromatase expression[5]. Atrazine exposure can decrease the expression and activity of DNMTs (DNA methyltransferase), leading to decreased DNA methylation levels[6].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00342121 - Completed - United States, Iowa ... 展开 >> University of Iowa Iowa City, Iowa, United States, 52242 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.64mL

0.93mL

0.46mL

23.18mL

4.64mL

2.32mL

46.37mL

9.27mL

4.64mL
参考文献

[2]Solomon KR, Giesy JP, LaPoint TW, Giddings JM, Richards RP. Ecological risk assessment of atrazine in North American surface waters. Environ Toxicol Chem. 2013 Jan;32(1):10-1

[3]Govers LC, Harper AP, Finger BJ, Mattiske DM, Pask AJ, Green MP. Atrazine induces penis abnormalities including hypospadias in mice. J Dev Orig Health Dis. 2020 Jun;11(3):246-249

[4]Fang Y, Ni C, Dong Y, Li H, Wu S, Li X, Lv Y, Huang T, Lian Q, Ge RS. In utero Exposure to Atrazine Disrupts Rat Fetal Testis Development. Front Pharmacol. 2018 Nov 28;9:1391

[5]Martins-Santos E, Pimenta CG, Campos PRN, Oliveira AG, Mahecha GAB, Oliveira CA. Atrazine affects the morphophysiology, tissue homeostasis and aromatase expression in the efferent ductules of adult rats with mild alterations in the ventral prostate. Chemosphere. 2018 Feb;193:958-967

[6]Wirbisky-Hershberger SE, Sanchez OF, Horzmann KA, Thanki D, Yuan C, Freeman JL. Atrazine exposure decreases the activity of DNMTs, global DNA methylation levels, and dnmt expression. Food Chem Toxicol. 2017 Nov;109(Pt 1):727-734