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Astragaloside IV

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Chemical Structure| 84687-43-4 同义名 : 黄芪皂苷 IV ;AS-IV;AST-IV
CAS号 : 84687-43-4
货号 : A491011
分子式 : C41H68O14
纯度 : 98%
分子量 : 784.97
MDL号 : MFCD16036240
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(133.76 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

PO 5%DMSO + 30%PEG400 + 1%tween80 + 64%Water 2 mg/mL clear

PO 10%DMSO+ SBE-β-CD water solution (20%) 2 mg/mL clear

生物活性
靶点

  • JNK
描述 Astragaloside IV(AS-IV) is a saponin from Astragalus membranaceus. Oral administration of AS-IV (10 and 20 mg/kg) significantly attenuated memory impairment and neuroinflammation[3]. High-dose astragaloside IV has a significant protective effect against D-GalN/LPS-induced (D-galactosamine/lipopolysaccharide-induced ) acute liver injury in mice [4]. High doses of astragaloside IV (10, 20, 40 ng/ml) inhibited NSCLC (non-small cell lung cancer ) cell growth[5]. Astragaloside IV inhibited the viability and invasive potential of MDA-MB-231 breast cancer cells, suppressed the activation of the mitogen activated protein kinase (MAPK) family members ERK1/2 and JNK, and downregulated matrix metalloproteases (MMP)-2 and -9[6].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01553643 Intracranial Arterial Stenosis Phase 4 Unknown - Taiwan ... 展开 >> China Medical University Hospital Recruiting Taiching, Taiwan Contact: Chung Hsiang Liu, MD. 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.27mL

0.25mL

0.13mL

6.37mL

1.27mL

0.64mL

12.74mL

2.55mL

1.27mL
参考文献

[1]Li M, Li H, et al. Astragaloside IV attenuates cognitive impairments induced by transient cerebral ischemia and reperfusion in mice via anti-inflammatory mechanisms. Neurosci Lett. 2017 Feb 3;639:114-119.

[2]Gui J, Chen R, et al. Remission of CVB3-induced myocarditis with Astragaloside IV treatment requires A20 (TNFAIP3) up-regulation. J Cell Mol Med. 2015 Apr;19(4):850-64.

[3]Li M, Li H, Fang F, Deng X, Ma S. Astragaloside IV attenuates cognitive impairments induced by transient cerebral ischemia and reperfusion in mice via anti-inflammatory mechanisms. Neurosci Lett. 2017 Feb 3;639:114-119. doi: 10.1016/j.neulet.2016.12.046. Epub 2016 Dec 21. PMID: 28011393.

[4]Liu L, Li SJ, Zhou Y. [Protective effect of astragaloside IV against acute liver failure in experimental mice]. Zhonghua Gan Zang Bing Za Zhi. 2016 Oct 20;24(10):772-777. Chinese. doi: 10.3760/cma.j.issn.1007-3418.2016.10.011. PMID: 27938564.

[6]Jiang K, Lu Q, Li Q, Ji Y, Chen W, Xue X. Astragaloside IV inhibits breast cancer cell invasion by suppressing Vav3 mediated Rac1/MAPK signaling. Int Immunopharmacol. 2017 Jan;42:195-202. doi: 10.1016/j.intimp.2016.10.001. Epub 2016 Dec 5. PMID: 27930970.