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芹菜甙 /Apiin {[allProObj[0].p_purity_real_show]}

货号:A101993 同义名: 芹菜苷 / Apigenin 7-apisoylglucoside;Apigenin 7-O-apioglucoside

Apiin can inhibit iNOS expression and nitrite production in J774.A1 cells. It is a flavonoid isolated from the herbs of petroselinum crispum.

Apiin 化学结构 CAS号:26544-34-3
Apiin 化学结构
CAS号:26544-34-3
Apiin 3D分子结构
CAS号:26544-34-3
Apiin 化学结构 CAS号:26544-34-3
Apiin 3D分子结构 CAS号:26544-34-3
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Apiin 纯度/质量文件 产品仅供科研

货号:A101993 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 eNOS iNOS nNOS 其他靶点 纯度
1400W 2HCl +

eNOS, Ki: 50 μM

++++

iNOS, Kd: <7 nM

++

nNOS, Ki: 2 μM

99%+
L-NAME HCl +++

eNOS, Ki: 39 nM

++

iNOS, Ki: 4.4 μM

+++

nNOS, Ki: 15 nM

98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Apiin 生物活性

描述 Apiin, a major constituent of Apium graveolens leaves with anti-inflammatory properties. Apiin shows significant inhibitory activity on nitrite (NO) production (IC50 = 0.08 mg/mL) in-vitro and iNOS expression (IC50 = 0.049 mg/ mL) in LPS-activated J774.A1 cells[3]. Apiin showed to be the most abundant phenolic compound in the extract. It also revealed the presence of many coumaric acid derivatives[4]. Apiin had a remarkable scavenging activity on MDA (maleic dialdehyde) and LPF (lipofuscin), promoted TAOC (total antioxidant capacity) and significantly enhanced the activities of SOD (superoxide dismutase), GSH-Px (glutathione peroxidase) and CAT (catalase) [5].

Apiin 参考文献

[1]Kasthuri J, Veerapandian S, Rajendiran N. Biological synthesis of silver and gold nanoparticles using apiin as reducing agent. Colloids Surf B Biointerfaces. 2009 Jan 1;68(1):55-60.

[2]Mencherini T, Cau A, et al. An extract of Apium graveolens var. dulce leaves: structure of the major constituent, apiin, and its anti-inflammatory properties. J Pharm Pharmacol. 2007 Jun;59(6):891-7.

[3]Mencherini T, Cau A, Bianco G, Della Loggia R, Aquino RP, Autore G. An extract of Apium graveolens var. dulce leaves: structure of the major constituent, apiin, and its anti-inflammatory properties. J Pharm Pharmacol. 2007 Jun;59(6):891-7

[4]Frattani FS, Assafim M, Casanova LM, de Souza JE, Chaves DSA, Costa SS, Zingali RB. Oral treatment with a chemically characterized parsley (Petroselinum crispum var. neapolitanum Danert) aqueous extract reduces thrombi formation in rats. J Tradit Complement Med. 2020 Apr 17;11(3):287-291

[5]Li P, Jia J, Zhang D, Xie J, Xu X, Wei D. In vitro and in vivo antioxidant activities of a flavonoid isolated from celery (Apium graveolens L. var. dulce). Food Funct. 2014 Jan;5(1):50-6

Apiin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.77mL

0.35mL

0.18mL

8.86mL

1.77mL

0.89mL

17.72mL

3.54mL

1.77mL

Apiin 技术信息

CAS号26544-34-3
分子式C26H28O14
分子量 564.492
别名 芹菜苷 ;Apigenin 7-apisoylglucoside;Apigenin 7-O-apioglucoside
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature

溶解度

DMSO: 105 mg/mL(186.01 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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