货号:A101993 同义名: 芹菜苷 / Apigenin 7-apisoylglucoside;Apigenin 7-O-apioglucoside
Apiin can inhibit iNOS expression and nitrite production in J774.A1 cells. It is a flavonoid isolated from the herbs of petroselinum crispum.
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产品名称 | eNOS ↓ ↑ | iNOS ↓ ↑ | nNOS ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1400W 2HCl |
+
eNOS, Ki: 50 μM |
++++
iNOS, Kd: <7 nM |
++
nNOS, Ki: 2 μM |
99%+ | |||||||||||||||
L-NAME HCl |
+++
eNOS, Ki: 39 nM |
++
iNOS, Ki: 4.4 μM |
+++
nNOS, Ki: 15 nM |
98% | |||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | Apiin, a major constituent of Apium graveolens leaves with anti-inflammatory properties. Apiin shows significant inhibitory activity on nitrite (NO) production (IC50 = 0.08 mg/mL) in-vitro and iNOS expression (IC50 = 0.049 mg/ mL) in LPS-activated J774.A1 cells[3]. Apiin showed to be the most abundant phenolic compound in the extract. It also revealed the presence of many coumaric acid derivatives[4]. Apiin had a remarkable scavenging activity on MDA (maleic dialdehyde) and LPF (lipofuscin), promoted TAOC (total antioxidant capacity) and significantly enhanced the activities of SOD (superoxide dismutase), GSH-Px (glutathione peroxidase) and CAT (catalase) [5]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
1.77mL 0.35mL 0.18mL |
8.86mL 1.77mL 0.89mL |
17.72mL 3.54mL 1.77mL |
CAS号 | 26544-34-3 |
分子式 | C26H28O14 |
分子量 | 564.492 |
别名 | 芹菜苷 ;Apigenin 7-apisoylglucoside;Apigenin 7-O-apioglucoside |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Inert atmosphere,Room Temperature |
溶解度 |
DMSO: 105 mg/mL(186.01 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |