Alvimopan is a peripherally selective opioid mu receptor antagonist.
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Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Alvimopan is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC50 of 1.7 nM[3]. Alvimopan has a greater affinity for the mu-receptor than the kappa- or sigma-opioid receptors (Ki = 0.77 nM). It has limited systemic bioavailability and higher affinity for the mu-opioid receptor than naloxone (Ki = 3.7 nM)[4]. Alvimopan (0.1-1.0 mg/kg; p.o.) partially antagonizes the slowing of small intestinal transit of 113Sn-labelled microspheres produced by morphine in rats. Alvimopan (3 mg/kg; p.o.) has no effect on the visceromotor behavioral responses (VMR) induced by noxious colorectal distension (CRD) in conscious rats[5]. Alvimopan showed significant advantages over placebo in restoring gastro-intestinal function, and reduced time to discharge following major abdominal surgery, with acceptable side effects[6]. Alvimopan significantly reduced the incidence of ileus and NGT (nasogastric tube) placement following RC(radical cystectomy). NGT placement was associated with an increased need for reoperation for bowel complications in the setting of alvimopan[7].
Terminated(Subject registratio... 展开 >>n did not proceed as expected; difficult to complete within scheduled time frame; prematurely terminated w/ 21 subjects randomized.) 收起 <<
United States, Wisconsin
... 展开 >>
Froedtert & the Medical College of Wisconsin
Recruiting
Milwaukee, Wisconsin, United States, 53226
Contact: Matthew I Goldblatt, MD 414-955-1770 mgoldbla@mcw.edu
Contact: Melissa C Helm, MSN, RN 414-955-1775 mhelm@mcw.edu
Sub-Investigator: Andrew S Kastenmeier, MD
Sub-Investigator: Cathyyen Dang, PharmD, BCPS 收起 <<
United States, California
... 展开 >>
Saddleback Memorial Medical Center
Laguna Hills, California, United States, 92653
United States, Colorado
University of Colorado Hospital
Aurora, Colorado, United States, 80045
United States, Florida
University of Miami
Miami, Florida, United States, 33136
H. Lee Moffitt Cancer Center & Research Institute
Tampa, Florida, United States, 33612
United States, Illinois
The University of Chicago Medical Center
Chicago, Illinois, United States, 60637
University of Chicago, Section of Urology MC6038
Chicago, Illinois, United States, 60637
United States, Indiana
Indiana University Hospital
Indianapolis, Indiana, United States, 46202
United States, Louisiana
Ochsner Clinic Foundation
New Orleans, Louisiana, United States, 70121
United States, Michigan
University of Michigan Health System
Ann Arbor, Michigan, United States, 48109
United States, Minnesota
University of Minnesota Hospital
Minneapolis, Minnesota, United States, 55455
Mayo Clinic
Rochester, Minnesota, United States, 55905
United States, Mississippi
CRC of Jackson
Jackson, Mississippi, United States, 39202
United States, North Carolina
University of North Carolina Hospitals
Chapel Hill, North Carolina, United States, 27599
Wake Forest University Baptist Medical Center
Winston-Salem, North Carolina, United States, 27157
United States, Ohio
Cleveland Clinic
Cleveland, Ohio, United States, 44195
United States, Oregon
Bend Memorial Clinic
Bend, Oregon, United States, 97701
Oregon Health and Science University Knight Cancer Institute
Portland, Oregon, United States, 97239
United States, Tennessee
Vanderbilt University Medical Center, Department of Urology Surgery
Nashville, Tennessee, United States, 37232
United States, Texas
The Methodist Hospital
Houston, Texas, United States, 77030
The University of Texas MD Anderson Cancer Center
Houston, Texas, United States, 77030 收起 <<
United States, Utah
... 展开 >>
American Fork Hospital
American Fork, Utah, United States, 84003
Valley View Hospital
Cedar City, Utah, United States, 84721
Logan Regional Hospital
Logan, Utah, United States, 84341
Intermoutain Medical Center
Murray, Utah, United States, 84157
McKay-Dee Hospital
Ogden, Utah, United States, 84403
Utah Valley
Provo, Utah, United States, 84604
LDS Hospital
Salt Lake City, Utah, United States, 84103
Alta View Hospital
Sandy, Utah, United States, 84094
Dixie Regional
St. George, Utah, United States, 84790 收起 <<
United States, Missouri
... 展开 >>
Barnes Jewish Hospital / Washington University in St. Louis School of Medicine
Saint Louis, Missouri, United States, 63108 收起 <<
United States, California
... 展开 >>
UCSD Moores Cancer Center
Recruiting
La Jolla, California, United States, 92093-0987
Contact: Joel M Baumgartner, MD, MAS 858-246-0581 j1baumgartner@ucsd.edu 收起 <<
United States, Virginia
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University of Virginia
Recruiting
Charlottesville, Virginia, United States, 22908
Contact: Marcia E Birk, RN 434-924-2283 meb2w@virginia.edu
Contact: Bhiken Naik, MBBCh 434-924-2283 bin4n@virginia.edu
Principal Investigator: Bhiken Naik, MBBCh 收起 <<
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