爱维莫潘二水合物 /Alvimopan dihydrate
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货号：A397796
同义名：
LY 246736 dihydrate;ADL 8-2698 dihydrate
Alvimopan is a peripherally acting mu-opioid receptor (PAM-OR, IC50= 1.7 nM) antagonist for accelerating gastrointestinal recovery after surgery.
Alvimopan dihydrate 化学结构
Alvimopan dihydrate 3D分子结构
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Alvimopan dihydrate 纯度/质量文件 产品仅供科研
货号：A397796
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Alvimopan dihydrate 质控信息
Racecadotril
✔
98%
JTC-801
++
Opioid receptor-like1 (ORL1), IC50: 94 nM
98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Alvimopan dihydrate 生物活性
描述
Alvimopan, a peripherally acting mu-opioid receptor antagonist, is a novel agent for the treatment of postoperative ileus[3] [4] [5] [6]
Alvimopan dihydrate 参考文献
[1] Fukuda H, Suenaga K, et al. The selective mu opioid receptor antagonist, alvimopan, improves delayed GI transit of postoperative ileus in rats. Brain Res. 2006 Aug 2;1102(1):63-70.
[2] Cassel JA, Daubert JD, et al. [(3)H] Alvimopan binding to the micro opioid receptor: comparative binding kinetics of opioid antagonists. Eur J Pharmacol. 2005 Sep 27;520(1-3):29-36.
[3] Bream-Rouwenhorst HR, Cantrell MA. Alvimopan for postoperative ileus. Am J Health Syst Pharm. 2009 Jul 15;66(14):1267-77
[4] Le Bourdonnec B, Barker WM, Belanger S, Wiant DD, Conway-James NC, Cassel JA, O'Neill TJ, Little PJ, DeHaven RN, DeHaven-Hudkins DL, Dolle RE. Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as mu opioid receptor antagonists with improved opioid receptor selectivity profiles. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2006-12
[5] Fukuda H, Suenaga K, Tsuchida D, Mantyh CR, Pappas TN, Hicks GA, Dehaven-Hudkins DL, Takahashi T. The selective mu opioid receptor antagonist, alvimopan, improves delayed GI transit of postoperative ileus in rats. Brain Res. 2006 Aug 2;1102(1):63-70
[6] Grundy D, Booth CE, Winchester W, Hicks GA. Peripheral opiate action on afferent fibres supplying the rat intestine. Neurogastroenterol Motil. 2004 Oct;16 Suppl 2:29-37
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Alvimopan dihydrate 实验方案
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摩尔计算器
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存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.17mL
0.43mL
0.22mL
10.86mL
2.17mL
1.09mL
21.71mL
4.34mL
2.17mL
Alvimopan dihydrate 技术信息
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