阿尔韦莱司他 /Alvelestat
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货号：A301653
同义名：
AZD9668;Avelestat
Alvelestat is an inhibitor of neutrophil elastase (NE) with the pIC50 of 7.9.
Alvelestat 化学结构
Alvelestat 3D分子结构
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Alvelestat 纯度/质量文件 产品仅供科研
货号：A301653
标准纯度：
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Alvelestat 质控信息
Alvelestat 生物活性
描述
Mutations in ELANE , the gene for neutrophil elastase (NE), a protease expressed early in neutrophil development, are the most frequent cause of cyclic (CyN) and severe congenital neutropenia (SCN)[3] 50 value of 7.9 nM, a Ki value of 9.4 nM and a Kd value of 9.5 nM[4] in vitro [5] in vivo [4]
Alvelestat 参考文献
[1] Makaryan V, Kelley ML, Fletcher B, Bolyard AA, Aprikyan AA, Dale DC. Elastase inhibitors as potential therapies for ELANE-associated neutropenia. J Leukoc Biol. 2017 Oct;102(4):1143-1151. doi: 10.1189/jlb.5A1016-445R. Epub 2017 Jul 28. PMID: 28754797; PMCID: PMC5597518.
[2] Stevens T, Ekholm K, Gränse M, Lindahl M, Kozma V, Jungar C, Ottosson T, Falk-Håkansson H, Churg A, Wright JL, Lal H, Sanfridson A. AZD9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase. J Pharmacol Exp Ther. 2011 Oct;339(1):313-20. doi: 10.1124/jpet.111.182139. Epub 2011 Jul 26. PMID: 21791628.
[3] Li H, Zhou X, Tan H, Hu Y, Zhang L, Liu S, Dai M, Li Y, Li Q, Mao Z, Pan P, Su X, Hu C. Neutrophil extracellular traps contribute to the pathogenesis of acid-aspiration-induced ALI/ARDS. Oncotarget. 2017 Nov 28;9(2):1772-1784. doi: 10.18632/oncotarget.22744. PMID: 29416730; PMCID: PMC5788598.
Alvelestat 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
1.83mL
0.37mL
0.18mL
9.17mL
1.83mL
0.92mL
18.33mL
3.67mL
1.83mL
Alvelestat 技术信息
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