阿仑膦酸钠 /Alendronate sodium hydrate
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货号：A136794
同义名：
阿仑膦酸钠三水合物
/ Alendronate;MK 217
Alendronate Sodium Trihydrate is an inhibitor of farnesyl diphosphate synthase with IC50 of 460 nM. It is used to treat osteoporosis.
Alendronate sodium hydrate 化学结构
Alendronate sodium hydrate 3D分子结构
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Alendronate sodium hydrate 纯度/质量文件 产品仅供科研
货号：A136794
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Alendronate sodium hydrate 质控信息
Alendronate sodium hydrate 生物活性
描述
Farnesyl diphosphate synthase (FDPS), a key enzyme in isoprenoid biosynthesis, catalyzes the conversion of isopentenyl pyrophosphate and dimethylallyl pyrophosphate to geranyl pyrophosphate and farnesyl pyrophosphate, which are protein prenylation substrates[3] 50 of 460 nM, used for the treatment and prevention of osteoporosis[4] [5] [6] [7]
Alendronate sodium hydrate 参考文献
[1] Bergstrom JD, Bostedor RG, et al. Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase. Arch Biochem Biophys. 2000 Jan 1;373(1):231-41.
[2] Fisher JE, Rogers MJ, et al. Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):133-8.
[3] Kim HY, Kim DK, Bae SH, Gwak H, Jeon JH, Kim JK, Lee BI, You HJ, Shin DH, Kim YH, Kim SY, Han SS, Shim JK, Lee JH, Kang SG, Jang H. Farnesyl diphosphate synthase is important for the maintenance of glioblastoma stemness. Exp Mol Med. 2018 Oct 17;50(10):1-12. doi: 10.1038/s12276-018-0166-2. PMID: 30333528; PMCID: PMC6193020.
[4] Bergstrom JD, Bostedor RG, Masarachia PJ, Reszka AA, Rodan G. Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase. Arch Biochem Biophys. 2000 Jan 1;373(1):231-41. doi: 10.1006/abbi.1999.1502. PMID: 10620343.
[5] Black DM, Cummings SR, Karpf DB, Cauley JA, Thompson DE, Nevitt MC, Bauer DC, Genant HK, Haskell WL, Marcus R, Ott SM, Torner JC, Quandt SA, Reiss TF, Ensrud KE. Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group. Lancet. 1996 Dec 7;348(9041):1535-41. doi: 10.1016/s0140-6736(96)07088-2. PMID: 8950879.
[6] Saag KG, Emkey R, Schnitzer TJ, Brown JP, Hawkins F, Goemaere S, Thamsborg G, Liberman UA, Delmas PD, Malice MP, Czachur M, Daifotis AG. Alendronate for the prevention and treatment of glucocorticoid-induced osteoporosis. Glucocorticoid-Induced Osteoporosis Intervention Study Group. N Engl J Med. 1998 Jul 30;339(5):292-9. doi: 10.1056/NEJM199807303390502. PMID: 9682041.
[7] Jackson NM, Kocarek TA. Suppression of CYP2B induction by alendronate-mediated farnesyl diphosphate synthase inhibition in primary cultured rat hepatocytes. Drug Metab Dispos. 2008 Oct;36(10):2030-6. doi: 10.1124/dmd.108.022558. Epub 2008 Jul 10. PMID: 18617600; PMCID: PMC2559974.
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Alendronate sodium hydrate 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
3.08mL
0.62mL
0.31mL
15.38mL
3.08mL
1.54mL
30.76mL
6.15mL
3.08mL
Alendronate sodium hydrate 技术信息
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