Adefovir is a NRTI used for treatment of hepatitis B and herpes simplex virus infection.
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
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描述 | The herpesviruses comprise a large family of viruses infecting most vertebrates. The virus particle is about 100 nm in diameter and consists of an icosahedral nucleocapsid surrounded by an outer membrane. A critical defining property of the herpesviruses is their ability to form a latent infection as part of their life cycle. Adefovir has been shown to have good antiviral activity against several viruses, including HIV and HBV, and herpesviruses, such as HSV (herpes simplex virus), EBV (Epstein–Barr virus), VZV (varicella zoster virus), and CMV (cytomegalovirus). Adefovir has an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line[3]. The effect of adefovir on viral CCC DNA (covalently closed circular DNA) synthesis was examined with primary cultures of DHBV (duck HBV)-infected fetal hepatocytes. Adefovir was administered for six consecutive days starting one day before or four days after DHBV inoculation. Dose-dependent inhibition of both virion release in culture supernatants and synthesis of intracellular viral DNA was observed. Preventive treatment of experimentally infected ducklings with adefovir revealed that it efficiently suppressed viremia and intrahepatic DNA[4]. The steady-state volume of distribution of adefovir in patients was found to be about 0.4 L/kg[3]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT00798460 | Chronic Hepatitis B | Phase 4 | Terminated(could not enroll pa... 展开 >>tients) 收起 << | - | Korea, Republic of ... 展开 >> Ilsanpaik hospital Goyang, Gyunggi, Korea, Republic of, 411-706 收起 << |
NCT02826070 | Hepatitis B, Chronic | Phase 4 | Unknown | October 2017 | China, Beijing ... 展开 >> 302 Military Hospital Of China Beijing, Beijing, China Beijing Ditan Hospital Beijing, Beijing, China BeiJing YouAn Hospital ,Capital Medical University Beijing, Beijing, China Department of infectious disease, First Hospital of Peking University Beijing, Beijing, China People's Hospital of Beijing University Beijing, Beijing, China China, Chongqing The Second Affiliated of ChongQing University of Medical Science Chongqing, Chongqing, China China, Guangdong Department of Infectious Disease, Nanfang Hospital Guangzhou, Guangdong, China No. 8 People's Hospital In GuangZhou Guangzhou, Guangdong, China The Third Hospital of Sun Yat-Sen University Guangzhou, Guangdong, China China, Hubei Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology Wuhan, Hubei, China China, Hunan Xiangya Hospital Central-South Univrsity Changsha, Hunan, China China, Jiangsu No.81 Hospital of PLA Nanjing, Jiangsu, China China, Jilin First Hospital .Jilin Unniversity Changchun, Jilin, China China, Liaoning ShengJing Hospital of China Medical University Shengyang, Liaoning, China China, Shandong JiNan Infectious Diseases Hospital Jinan, Shandong, China China, Shanghai Changhai Hospital affiliated to Second Military Medical University Shanghai, Shanghai, China Huashan Hospital,Fudan University Shanghai, Shanghai, China Shanghai Ruijin Hospital Shanghai, Shanghai, China China, Shanxi Tangdu Hospital XiAn, Shanxi, China China, Zhejiang The First Affiliated Hospital of College of Medicine, Zhejiang University Hangzhou, Zhejiang, China 收起 << |
NCT00199732 | - | Completed | - | France ... 展开 >> Service d'Hépato-gastroentérologie Limoges, France Service de Médecine Interne Limoges, France Service de Virologie Limoges, France Service des Maladies Infectieuses et Tropicales Limoges, France 收起 << | |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
3.66mL 0.73mL 0.37mL |
18.30mL 3.66mL 1.83mL |
36.61mL 7.32mL 3.66mL |
CAS号 | 106941-25-7 |
分子式 | C8H12N5O4P |
分子量 | 273.186 |
别名 | GS-0393;PMEA |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
溶解度 |
H2O: 1 mg/mL(3.66 mM),配合低频超声,并水浴加热至45℃助溶 0.1 M NaOH: 10 mg/mL(36.61 mM),配合低频超声,并调节pH至10 |
动物实验配方 |