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阿德福韦 /Adefovir {[allProObj[0].p_purity_real_show]}

货号:A176069 同义名: GS-0393;PMEA

Adefovir is a NRTI used for treatment of hepatitis B and herpes simplex virus infection.

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Adefovir 化学结构 CAS号:106941-25-7
Adefovir 化学结构
CAS号:106941-25-7
Adefovir 3D分子结构
CAS号:106941-25-7
Adefovir 化学结构 CAS号:106941-25-7
Adefovir 3D分子结构 CAS号:106941-25-7
规格 价格 会员价 库存 数量
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Adefovir 纯度/质量文件 产品仅供科研

货号:A176069 标准纯度: {[allProObj[0].p_purity_real_show]}
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Adefovir 生物活性

描述 The herpesviruses comprise a large family of viruses infecting most vertebrates. The virus particle is about 100 nm in diameter and consists of an icosahedral nucleocapsid surrounded by an outer membrane. A critical defining property of the herpesviruses is their ability to form a latent infection as part of their life cycle. Adefovir has been shown to have good antiviral activity against several viruses, including HIV and HBV, and herpesviruses, such as HSV (herpes simplex virus), EBV (Epstein–Barr virus), VZV (varicella zoster virus), and CMV (cytomegalovirus). Adefovir has an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line[3]. The effect of adefovir on viral CCC DNA (covalently closed circular DNA) synthesis was examined with primary cultures of DHBV (duck HBV)-infected fetal hepatocytes. Adefovir was administered for six consecutive days starting one day before or four days after DHBV inoculation. Dose-dependent inhibition of both virion release in culture supernatants and synthesis of intracellular viral DNA was observed. Preventive treatment of experimentally infected ducklings with adefovir revealed that it efficiently suppressed viremia and intrahepatic DNA[4]. The steady-state volume of distribution of adefovir in patients was found to be about 0.4 L/kg[3].

Adefovir 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00798460 Chronic Hepatitis B Phase 4 Terminated(could not enroll pa... 展开 >>tients) 收起 << - Korea, Republic of ... 展开 >> Ilsanpaik hospital Goyang, Gyunggi, Korea, Republic of, 411-706 收起 <<
NCT02826070 Hepatitis B, Chronic Phase 4 Unknown October 2017 China, Beijing ... 展开 >> 302 Military Hospital Of China Beijing, Beijing, China Beijing Ditan Hospital Beijing, Beijing, China BeiJing YouAn Hospital ,Capital Medical University Beijing, Beijing, China Department of infectious disease, First Hospital of Peking University Beijing, Beijing, China People's Hospital of Beijing University Beijing, Beijing, China China, Chongqing The Second Affiliated of ChongQing University of Medical Science Chongqing, Chongqing, China China, Guangdong Department of Infectious Disease, Nanfang Hospital Guangzhou, Guangdong, China No. 8 People's Hospital In GuangZhou Guangzhou, Guangdong, China The Third Hospital of Sun Yat-Sen University Guangzhou, Guangdong, China China, Hubei Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology Wuhan, Hubei, China China, Hunan Xiangya Hospital Central-South Univrsity Changsha, Hunan, China China, Jiangsu No.81 Hospital of PLA Nanjing, Jiangsu, China China, Jilin First Hospital .Jilin Unniversity Changchun, Jilin, China China, Liaoning ShengJing Hospital of China Medical University Shengyang, Liaoning, China China, Shandong JiNan Infectious Diseases Hospital Jinan, Shandong, China China, Shanghai Changhai Hospital affiliated to Second Military Medical University Shanghai, Shanghai, China Huashan Hospital,Fudan University Shanghai, Shanghai, China Shanghai Ruijin Hospital Shanghai, Shanghai, China China, Shanxi Tangdu Hospital XiAn, Shanxi, China China, Zhejiang The First Affiliated Hospital of College of Medicine, Zhejiang University Hangzhou, Zhejiang, China 收起 <<
NCT00199732 - Completed - France ... 展开 >> Service d'Hépato-gastroentérologie Limoges, France Service de Médecine Interne Limoges, France Service de Virologie Limoges, France Service des Maladies Infectieuses et Tropicales Limoges, France 收起 <<

Adefovir 参考文献

[1]Hachiya A, Kodama EN, et al. K70Q adds high-level tenofovir resistance to "Q151M complex" HIV reverse transcriptase through the enhanced discrimination mechanism. PLoS One. 2011 Jan 13;6(1):e16242.

[2]Perno CF, Yarchoan R, et al. Different pattern of activity of inhibitors of the human immunodeficiency virus in lymphocytes and monocyte/macrophages. Antiviral Res. 1992 Apr;17(4):289-304.

[3]7.11 - Deoxyribonucleic Acid Viruses: Antivirals for Herpesviruses and Hepatitis B Virus

[4]Delmas J, Schorr O, Jamard C, et al. Inhibitory effect of adefovir on viral DNA synthesis and covalently closed circular DNA formation in duck hepatitis B virus-infected hepatocytes in vivo and in vitro. Antimicrob Agents Chemother. 2002;46(2):425–433

Adefovir 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.66mL

0.73mL

0.37mL

18.30mL

3.66mL

1.83mL

36.61mL

7.32mL

3.66mL

Adefovir 技术信息

CAS号106941-25-7
分子式C8H12N5O4P
分子量 273.186
别名 GS-0393;PMEA
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

溶解度

H2O: 1 mg/mL(3.66 mM),配合低频超声,并水浴加热至45℃助溶

0.1 M NaOH: 10 mg/mL(36.61 mM),配合低频超声,并调节pH至10

动物实验配方
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