阿西鲁司特 /Acebilustat
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货号：A639379
同义名：
CTX-4430
Acebilustat is a leukotriene A4 hydrolase inhibitor, used for an oral antiinflammatory drug.
Acebilustat 化学结构
Acebilustat 3D分子结构
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Acebilustat 纯度/质量文件 产品仅供科研
货号：A639379
标准纯度：
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Acebilustat 质控信息
Acebilustat 生物活性
描述
Leukotriene B4 (LTB4) is a potent chemoattractant of neutrophil migration and activation. Leukotriene A4 hydrolase (LTA4H) is the rate‐limiting enzyme for LTB4 synthesis. Reducing the production of LTB4 via inhibiting LTA4H may be a potential therapeutic approach for anti-inflammatory treatment. Acebilustat is a potent inhibitor of LTA4H. The IC50 value of acebilustat for the inhibition of LTB4 production in human whole blood is 31ng/mL (~0.064μM)[3] [4]
Acebilustat 参考文献
[1] Elborn JS, Horsley A, et al. Phase I Studies of Acebilustat: Biomarker Response and Safety in Patients with Cystic Fibrosis. Clin Transl Sci. 2017 Jan;10(1):28-34.
[2] Elborn JS, Bhatt L, et al. Phase I Studies of Acebilustat: Pharmacokinetics, Pharmacodynamics, Food Effect, and CYP3A Induction. Clin Transl Sci. 2017 Jan;10(1):20-27.
[3] Elborn JS, Bhatt L, Grosswald R, Ahuja S, Springman EB. Phase I Studies of Acebilustat: Pharmacokinetics, Pharmacodynamics, Food Effect, and CYP3A Induction. Clin Transl Sci. 2017 Jan;10(1):20-27.
[4] Forrest OA, Ingersoll SA, Preininger MK, Laval J, Limoli DH, Brown MR, Lee FE, Bedi B, Sadikot RT, Goldberg JB, Tangpricha V, Gaggar A, Tirouvanziam R. Frontline Science: Pathological conditioning of human neutrophils recruited to the airway milieu in cystic fibrosis. J Leukoc Biol. 2018 Oct;104(4):665-675.
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Acebilustat 实验方案
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存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.08mL
0.42mL
0.21mL
10.38mL
2.08mL
1.04mL
20.77mL
4.15mL
2.08mL
Acebilustat 技术信息
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