Acebilustat
产品说明书
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同义名 : | CTX-4430 |
| CAS号 : | 943764-99-6 | |
| 货号 : | A639379 | |
| 分子式 : | C29H27N3O4 | |
| 纯度 : | 99%+ | |
| 分子量 : | 481.542 | |
| MDL号 : | MFCD30496703 | |
| 存储条件： |
Pure form Sealed in dry,Store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 16 mg/mL(33.23 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Leukotriene B4 (LTB4) is a potent chemoattractant of neutrophil migration and activation. Leukotriene A4 hydrolase (LTA4H) is the rate‐limiting enzyme for LTB4 synthesis. Reducing the production of LTB4 via inhibiting LTA4H may be a potential therapeutic approach for anti-inflammatory treatment. Acebilustat is a potent inhibitor of LTA4H. The IC50 value of acebilustat for the inhibition of LTB4 production in human whole blood is 31ng/mL (~0.064μM)[3]. Acebilustat at a concentration of 0.1μM decreased the count of apical polymorphonuclear neutrophils at 2-, 10- and 18-hour post-transmigration without affecting primary granule exocytosis in these cells[4]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.08mL 0.42mL 0.21mL |
10.38mL 2.08mL 1.04mL |
20.77mL 4.15mL 2.08mL |
| 参考文献 |
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