AX20017
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货号：A499106
AX20017 是一种小分子蛋白激酶G（PknG）抑制剂，IC50为0.39 μM。
AX20017 化学结构
AX20017 3D分子结构
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AX20017 纯度/质量文件 产品仅供科研
货号：A499106
标准纯度：
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AX20017 质控信息
AX20017 生物活性
描述
AX20017 is a small-molecule protein kinase G (PknG) inhibitor with an IC50 of 0.39 μM[3] [4] [5] [6]
AX20017 参考文献
[1] Santhi N, Aishwarya S. Insights from the molecular docking of withanolide derivatives to the target protein PknG from Mycobacterium tuberculosis. Bioinformation. 2011;7(1):1-4.
[2] Walburger A, Koul A, et al. Protein kinase G from pathogenic mycobacteria promotes survival within macrophages. Science. 2004 Jun 18;304(5678):1800-4.
[3] Walburger A, Koul A, Ferrari G, Nguyen L, Prescianotto-Baschong C, Huygen K, Klebl B, Thompson C, Bacher G, Pieters J. Protein kinase G from pathogenic mycobacteria promotes survival within macrophages. Science. 2004 Jun 18;304(5678):1800-4
[4] Khan MZ, Nandicoori VK. Deletion of pknG Abates Reactivation of Latent Mycobacterium tuberculosis in Mice. Antimicrob Agents Chemother. 2021 Mar 18;65(4):e02095-20
[5] Scherr N, Honnappa S, Kunz G, Mueller P, Jayachandran R, Winkler F, Pieters J, Steinmetz MO. Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12151-6
[6] Santhi N, Aishwarya S. Insights from the molecular docking of withanolide derivatives to the target protein PknG from Mycobacterium tuberculosis. Bioinformation. 2011;7(1):1-4
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AX20017 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
3.78mL
0.76mL
0.38mL
18.92mL
3.78mL
1.89mL
37.83mL
7.57mL
3.78mL
AX20017 技术信息
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