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AA147 {[allProObj[0].p_purity_real_show]}

货号：A1206252

AA147 is an ATF6 simulator which acts as a prodrug that preferentially triggers ATF6 signaling.

AA147 化学结构 CAS号：393121-74-9
AA147 化学结构
CAS号：393121-74-9
AA147 3D分子结构
CAS号：393121-74-9
AA147 化学结构 CAS号：393121-74-9
AA147 3D分子结构 CAS号：393121-74-9
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AA147 纯度/质量文件 产品仅供科研

货号：A1206252 标准纯度： {[allProObj[0].p_purity_real_show]}
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AA147 生物活性

描述 AA147 is an endoplasmic reticulum (ER) proteostasis regulator. It enhances protection against oxidative damage in neuronal cells and prevents endothelial barrier dysfunction by selectively activating the ATF6 arm of the unfolded protein response (UPR) and the NRF2 oxidative stress response. In vivo, AA147 rebalances XBP1s expression and induces survival motor neuron (SMN) expression, thereby protecting spinal motor neurons [1][2][3][4].
体内研究

AA147 (intrathecal injection; single for 3 days) rebalances XBP1s expression in severe SMA-like mice by activating ATF6. Additionally, it induces expression of survival motor neuron and protects spinal motor neurons [3].
体外研究

AA147 (20-0.078 μM (dilution in half); 6 or 16 h) shields against glutamate-induced oxidative toxicity in HT22 cells by reducing reactive oxygen species (ROS)-associated damage [1].

AA147 (10 μM; 16 h) triggers NRF2-dependent upregulation of oxidative stress response genes in HT22 cells [1].

AA147 (10 μM; 16 h) covalently alters KEAP1 to enhance NRF2 activation in HT22 cells [1].

AA147 (5, 10, 15 μM; 4, 8, 16, 24, 48 h) triggers ATF6 activation and increases phosphorylation of cofilin in BPAEC [2].

AA147 (10 μM; 24 h) mitigates LPS-induced endothelial barrier disruption in BPAEC [2].

AA147 (5, 10 μM; 135 h) improves lung endothelial barrier integrity [2].

AA147 参考文献

[1]Rosarda JD, et al. Metabolically Activated Proteostasis Regulators Protect against Glutamate Toxicity by Activating NRF2. ACS Chem Biol. 2021 Dec 17;16(12):2852-2863.

[2]Kubra KT, et al. Activating transcription factor 6 protects against endothelial barrier dysfunction. Cell Signal. 2022 Aug 4;99:110432.

[3]D'Amico D, et al. Activating ATF6 in spinal muscular atrophy promotes SMN expression and motor neuron survival through the IRE1α-XBP1 pathway. Neuropathol Appl Neurobiol. 2022 Aug;48(5):e12816.

[4]Christina COOLEY, et al. Regulators of the endoplasmic reticulum proteostasis network. WO2017117430A1.

AA147 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.92mL

0.78mL

0.39mL

19.58mL

3.92mL

1.96mL

39.17mL

7.83mL

3.92mL

AA147 技术信息

CAS号393121-74-9
分子式C16H17NO2
分子量 255.312
别名
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Room Temperature
溶解度

DMSO: 50 mg/mL(195.84 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: AA147 | 393121-74-9 | AA 147 | AA-147 | ATF6 | Cell Cycle/DNA Damage | NF-κB | Metabolic Enzyme/Protease | Immunology/Inflammation | ATF6 | Reactive Oxygen Species | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | AA147 纯度/质量文件 | AA147 生物活性 | AA147 参考文献 | AA147 实验方案 | AA147 技术信息

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