产品说明书
AA147
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同义名 : | - |
| CAS号 : | 393121-74-9 | |
| 货号 : | A1206252 | |
| 分子式 : | C16H17NO2 | |
| 纯度 : | 99%+ | |
| 分子量 : | 255.312 | |
| MDL号 : | MFCD01881999 | |
| 存储条件： |
粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(195.84 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | AA147 is an endoplasmic reticulum (ER) proteostasis regulator. It enhances protection against oxidative damage in neuronal cells and prevents endothelial barrier dysfunction by selectively activating the ATF6 arm of the unfolded protein response (UPR) and the NRF2 oxidative stress response. In vivo, AA147 rebalances XBP1s expression and induces survival motor neuron (SMN) expression, thereby protecting spinal motor neurons [1][2][3][4]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.92mL 0.78mL 0.39mL |
19.58mL 3.92mL 1.96mL |
39.17mL 7.83mL 3.92mL |
| 参考文献 |
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