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首页 / 抑制剂/激动剂 / 抗感染 / Antibacterial / 5-Hydroxypyrazine-2-Carboxylic Acid

5-Hydroxypyrazine-2-Carboxylic Acid {[allProObj[0].p_purity_real_show]}

货号：A219158

5-Hydroxypyrazine-2-Carboxylic Acid是一种吡嗪酰胺 (PZA) 的代谢产物，具有抗肺结核活性。

5-Hydroxypyrazine-2-Carboxylic Acid 化学结构 CAS号：34604-60-9
5-Hydroxypyrazine-2-Carboxylic Acid 化学结构
CAS号：34604-60-9
5-Hydroxypyrazine-2-Carboxylic Acid 3D分子结构
CAS号：34604-60-9
5-Hydroxypyrazine-2-Carboxylic Acid 化学结构 CAS号：34604-60-9
5-Hydroxypyrazine-2-Carboxylic Acid 3D分子结构 CAS号：34604-60-9
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5-Hydroxypyrazine-2-Carboxylic Acid 纯度/质量文件 产品仅供科研

货号：A219158 标准纯度： {[allProObj[0].p_purity_real_show]}
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5-Hydroxypyrazine-2-Carboxylic Acid 生物活性

描述 5-Hydroxypyrazine-2-Carboxylic Acid, a metabolite of anti-tuberculosis drug pyrazinamide (PZA). The PZA metabolite pyrazinoic acid (PA) is the active compound against M. tuberculosis. PZA and caffeine, in various doses (PZA=50 or 100 mg kg(-1) and caffeine= 0, 50, 100, and 150 mg kg(-1)), were administered to female Sprague-Dawley rats. PZA and its three main metabolites were quantified in 24 h urine samples by reversed phase-HPLC Concomitant administration of 100 mg kg(-1) caffeine and 50 mg kg(-1) PZA increased from the excretion (p<0.05) of the most water-soluble and the least toxic PZA metabolite 5-hydroxypyrazinoic acid (5-OH-PA) from 66.18+/-10.87 to 94.56+/-8.65 micromol/24 h. This effect was more pronounced when 100 mg kg(-1) of PZA was administered increasing excretion of 5-OH-PA from 113.28+/-70 to 173.23+/-17.82 micromol/24 h[1]. 5OH-PYCA dissociates in two steps, with the corresponding dissociation constants pK (a1)=3.42 and pK (a2)=7.96, designating 5OH-PYCA as a medium weak acid[2].

5-Hydroxypyrazine-2-Carboxylic Acid 参考文献

[1]Mehmedagic A, Verite P, Menager S, et al. Investigation of the effects of concomitant caffeine administration on the metabolic disposition of pyrazinamide in rats. Biopharm Drug Dispos. 2002;23(5):191‐195

[2]Sak-Bosnar M, Kovar K. Acid-base characterization of 5-hydroxypyrazine-2-carboxylic acid and the role of ionic equilibria in the optimization of some process conditions for its biocatalytic production. Anal Bioanal Chem. 2005;383(3):539‐545

5-Hydroxypyrazine-2-Carboxylic Acid 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

7.14mL

1.43mL

0.71mL

35.69mL

7.14mL

3.57mL

71.38mL

14.28mL

7.14mL

5-Hydroxypyrazine-2-Carboxylic Acid 技术信息

CAS号34604-60-9
分子式C5H4N2O3
分子量 140.1
SMILES Code O=C(C1=CNC(C=N1)=O)O
MDL No. MFCD11978170
别名
运输蓝冰
InChI Key CGQFCIHUUCMACC-UHFFFAOYSA-N
Pubchem ID 161825
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry, room temperature
溶解方案

DMSO: 50 mg/mL(356.89 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 4 mg/mL(28.55 mM)，配合低频超声助溶

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案一
方案二

Tags: 5-Hydroxypyrazine-2-Carboxylic Acid | 34604-60-9 | Bacterial Inhibitor | Anti-infection | Bacterial | Antibiotic | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | 5-Hydroxypyrazine-2-Carboxylic Acid 纯度/质量文件 | 5-Hydroxypyrazine-2-Carboxylic Acid 生物活性 | 5-Hydroxypyrazine-2-Carboxylic Acid 参考文献 | 5-Hydroxypyrazine-2-Carboxylic Acid 实验方案 | 5-Hydroxypyrazine-2-Carboxylic Acid 技术信息

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