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5-羟甲基-2'-脱氧尿苷 /5-Hydroxymethyl-2'-deoxyuridine {[allProObj[0].p_purity_real_show]}

货号：A268668 同义名： 5-(Hydroxymethyl)-2’-deoxyuridine Ambeed 开学季，买赠积分，赢豪礼

5-Hydroxymethyl-2'-deoxyuridine是一种核苷类似物，能够有效抑制多种人类白血病细胞系的增殖，IC50 范围为 1.7-5.8 μM。该化合物在白血病模型中延长了小鼠的存活时间，适用于白血病和细胞增殖的相关研究。

5-Hydroxymethyl-2'-deoxyuridine 化学结构 CAS号：5116-24-5
5-Hydroxymethyl-2'-deoxyuridine 化学结构
CAS号：5116-24-5
5-Hydroxymethyl-2'-deoxyuridine 3D分子结构
CAS号：5116-24-5
5-Hydroxymethyl-2'-deoxyuridine 化学结构 CAS号：5116-24-5
5-Hydroxymethyl-2'-deoxyuridine 3D分子结构 CAS号：5116-24-5
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5-Hydroxymethyl-2'-deoxyuridine 纯度/质量文件 产品仅供科研

货号：A268668 标准纯度： {[allProObj[0].p_purity_real_show]}
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5-Hydroxymethyl-2'-deoxyuridine 生物活性

描述 5-Hydroxymethyl-2'-deoxyuridine (HMdU) is a nucleoside analog known for inhibiting the replication of various human leukemia cell lines, exhibiting IC50 values ranging from 1.7 to 5.8 μM. HMdU also extends the lifespan of mice with L1210 leukemia. It is applicable for investigating cell replication and leukemia[1][2][3].
体内研究

5-Hydroxymethyl-2'-deoxyuridine (0, 5 and 50 mg/kg; i.p.; once) enhances the survival of DBA/2 mice with L1210 leukemia[3].
体外研究

5-Hydroxymethyl-2'-deoxyuridine (0-10 μM) suppresses the replication of Sarcoma 180 cells and Ehrlich ascites carcinoma cells, with ED50 values of 8.5 and 4 μM, respectively.

5-Hydroxymethyl-2'-deoxyuridine suppresses the activity of herpes simplex virus type 1 (HSV-1) pyrimidine 2’-deoxyribonucleoside kinase, with a Ki value of 3.5 μM[1].

5-Hydroxymethyl-2'-deoxyuridine suppresses the replication of various human leukemia cell lines, exhibiting IC50 values ranging from 1.7 to 5.8 μM[2].

5-Hydroxymethyl-2'-deoxyuridine (10-100 μM) exhibits dose-dependent toxicity against a human acute promyelocytic leukemia cell line[2].

5-Hydroxymethyl-2'-deoxyuridine 参考文献

[1]Shiau GT, et al. Synthesis and biological activities of 5-(hydroxymethyl, azidomethyl, or aminomethyl)-2'-deoxyuridine and related 5'-substituted analogues. J Med Chem. 1980 Feb;23(2):127-33.

[2]Kahilainen LI, et al. 5-Hydroxymethyl-2'-deoxyuridine. Cytotoxicity and DNA incorporation studied by using a novel [2-14C]-derivative with normal and leukemic human hematopoietic cells. Acta Chem Scand B. 1985;39(6):477-84.

[3]JA Vilpo, et al. 5-Hydroxymethyl-2′-Deoxyuridine: Studies of Antileukemic Properties in Vitro and in Vivo. Nucleosides and Nucleotides . 1987.

5-Hydroxymethyl-2'-deoxyuridine 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.87mL

0.77mL

0.39mL

19.36mL

3.87mL

1.94mL

38.73mL

7.75mL

3.87mL

5-Hydroxymethyl-2'-deoxyuridine 技术信息

CAS号5116-24-5
分子式C10H14N2O6
分子量 258.228
别名 5-(Hydroxymethyl)-2’-deoxyuridine
运输蓝冰
存储条件

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 120 mg/mL(464.71 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: 5-Hydroxymethyl-2'-deoxyuridine | 5116-24-5 | HSV | Herpes simplex virus | Anti-infection | HSV | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | 5-Hydroxymethyl-2'-deoxyuridine 纯度/质量文件 | 5-Hydroxymethyl-2'-deoxyuridine 生物活性 | 5-Hydroxymethyl-2'-deoxyuridine 参考文献 | 5-Hydroxymethyl-2'-deoxyuridine 实验方案 | 5-Hydroxymethyl-2'-deoxyuridine 技术信息

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