货号:A340721 同义名: 5-氨基乙酰丙酸盐酸盐;氨基酮戊酸 / 5-ALA hydrochloride;δ-Aminolevulinic acid hydrochloride
5-Aminolevulinic acid HCl能够激活或抑制HeLa和K562细胞系中的血红素生物合成,用作光化学疗法治疗日光角化症。
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描述 | 5-Aminolevulinic acid hydrochloride is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT02660645 | - | Recruiting | December 2020 | United States, California ... 展开 >> USC/Norris Comprehensive Cancer Center Recruiting Los Angeles, California, United States, 90033 Contact: Ileana Aldana 323-865-0702 ileana.aldana@med.usc.edu Principal Investigator: Sia Daneshmand, MD Sub-Investigator: Anne Schuckman, MD Sub-Investigator: Mihir Desai, MD Sub-Investigator: Hooman Djaladat, MD Sub-Investigator: Gerhard Fuchs, MD Sub-Investigator: Virinder Bhardwaj, MD VA Palo Alto Health Care System Recruiting Palo Alto, California, United States, 94304 Contact: Dorothy Trivedi dtrivedi@stanford.edu Principal Investigator: Joseph Liao, MD Sub-Investigator: James Crotty, MD Sub-Investigator: John Leppert, MD Sub-Investigator: John Lavelle, MD University of California, San Francisco Recruiting San Francisco, California, United States, 94143 Contact: Sima Porten, MD, MPH 415-885-3695 Sima.Porten@ucsf.edu Principal Investigator: Sima Porten, MD, MPH United States, Kansas University of Kansas Medical Center Recruiting Kansas City, Kansas, United States, 66160 Contact: Katie Glavin 913-588-8721 kglavin@kumc.edu Principal Investigator: John Taylor, MD, MS Sub-Investigator: Jeffrey Holzbeierlein, MD, FACS Sub-Investigator: Eugene Lee, MD, FACS Sub-Investigator: Hadley Wyre, MD Sub-Investigator: Moben Mirza, MD United States, Maryland Johns Hopkins Medicine Recruiting Baltimore, Maryland, United States, 21224 Contact: Morgan De Carli Mdecarl2@jhmi.edu Principal Investigator: Trinity Bivalacqua, MD, PhD Sub-Investigator: Phillip Pierorazio, MD United States, Minnesota University of Minnesota Recruiting Minneapolis, Minnesota, United States, 55455 Contact: Therese Perrier 612-625-3319 perri084@umn.edu Principal Investigator: Badrinath Konety, MD Sub-Investigator: Weight Chris, MD Sub-Investigator: Laureen Hemsley, MD United States, New York Stony Brook Urology Recruiting Stony Brook, New York, United States, 11794 Contact: Kim Lyktey Kim.Lyktey@stonybrookmedicine.edu Principal Investigator: John Fitzgerald, MD Sub-Investigator: Massimiliano Spaliviero, MD Sub-Investigator: Wayne Waltzer, MD United States, Ohio Cincinnati VA Medical Center Not yet recruiting Cincinnati, Ohio, United States, 45220 Contact: Krishnanath Gaitonde, MD Principal Investigator: Krishnanath Gaitonde, MD Ohio State University Wexner Medical Center Recruiting Columbus, Ohio, United States, 43210 Contact: Kamal Pohar, MD kamal.pohar@osumc.edu Principal Investigator: Kamal Pohar, MD Sub-Investigator: Megan Merrill, DO Sub-Investigator: Ahmad Shabsigh, MD Sub-Investigator: David Sharp, MD United States, South Carolina Carolina Urology Partners Recruiting West Columbia, South Carolina, United States, 29169 Contact: Nicol Brandon 704-414-2870 ext 2809 Nicol.brandon@carolinaurologypartners.com Principal Investigator: T. Brian Willard, MD Sub-Investigator: David Lamb, MD Sub-Investigator: Scott Sweazy, MD Sub-Investigator: Keith Birghtbill, MD Sub-Investigator: Michael Stotzer, MD United States, Texas UT Southwestern Not yet recruiting Dallas, Texas, United States, 75390 Contact: Yair Lotan, MD 214-645-8787 Principal Investigator: Yair Lotan, MD Sub-Investigator: Aditya Bagrodia, MD Sub-Investigator: Vitaly Margulis, MD Sub-Investigator: Ganesh Raj, MD, PhD Michael E. DeBakey VA Medical Center Recruiting Houston, Texas, United States, 77030 Contact: Ashley Jones, BS, CCRP 713-791-1414 ext 26694 Ashley.Jones2@bcm.edu Principal Investigator: Jennifer Taylor, MD, MPH Sub-Investigator: Jeffrey Jones, MD Sub-Investigator: Sidney Worsham, MD United States, West Virginia Charleston Area Medical Center Recruiting Charleston, West Virginia, United States, 25301 Contact: James Tierney, DO 304-388-9944 Principal Investigator: James Tierney, DO Sub-Investigator: Samuel Deem, DO 收起 << | |
NCT02560584 | Bladder Cancer | Phase 3 | Completed | - | United States, California ... 展开 >> USC Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 United States, Illinois University of Chicago Medical Center Chicago, Illinois, United States, 60637 United States, Iowa University of Iowa Iowa City, Iowa, United States, 52242 United States, Maryland Johns Hopkins University Baltimore, Maryland, United States, 21205 United States, Minnesota University of Minnesota Minneapolis, Minnesota, United States, 55455 United States, New York Montefiore Medical Center Bronx, New York, United States, 10461 NYU Langone Urology Associates New York, New York, United States, 10016 Columbia University Medical Center New York, New York, United States, 10032 United States, North Carolina University of North Carolina, Department of Urology Chapel Hill, North Carolina, United States, 27599 United States, Ohio Ohio State University The James Cancer Hospital Columbus, Ohio, United States, 43210 United States, Oklahoma University of Oklahoma-Stephenson Cancer Center Oklahoma City, Oklahoma, United States, 73104 United States, Pennsylvania Thomas Jefferson University Philadelphia, Pennsylvania, United States, 10197 United States, Tennessee Vanderbilt University Medical Center Nashville, Tennessee, United States, 37232 United States, Texas UT Southwestern Medical Center Dallas, Texas, United States, 75390 MD Anderson Cancer Center Houston, Texas, United States, 77030 Michael E. DeBakey VA Medical Center Houston, Texas, United States, 77030 United States, Wisconsin University of Wisconsin Madison, Wisconsin, United States, 53792 收起 << |
NCT01050309 | Pharmacokinetics | Phase 1 | Completed | - | Netherlands ... 展开 >> Pra-Eds-Nl Zuidlaren, Netherlands, 9471 收起 << |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
5.97mL 1.19mL 0.60mL |
29.83mL 5.97mL 2.98mL |
59.67mL 11.93mL 5.97mL |
CAS号 | 5451-09-2 |
分子式 | C5H10ClNO3 |
分子量 | 167.591 |
别名 | 5-氨基乙酰丙酸盐酸盐;氨基酮戊酸;5-氨基-4-氧代戊酸盐酸盐 ;5-ALA hydrochloride;δ-Aminolevulinic acid hydrochloride;δ-Aminolevulinic Acid;5-ALA;5-Aminolevulinic Acid (hydrochloride);5-Amino-4-oxopentanoic acid hydrochloride;5-Aminolevulinic acid hydrochloride |
运输 | 蓝冰 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Inert atmosphere,Store in freezer, under -20°C |
溶解度 |
DMSO: 105 mg/mL(626.53 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 15 mg/mL(89.5 mM),配合低频超声,并水浴加热至45℃助溶 |
动物实验配方 |