5-Aminolevulinic acid HCl

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Chemical Structure| 5451-09-2 同义名 : 5-氨基乙酰丙酸盐酸盐;氨基酮戊酸;5-氨基-4-氧代戊酸盐酸盐 ;5-ALA hydrochloride;δ-Aminolevulinic acid hydrochloride;δ-Aminolevulinic Acid;5-ALA;5-Aminolevulinic Acid (hydrochloride);5-Amino-4-oxopentanoic acid hydrochloride;5-Aminolevulinic acid hydrochloride
CAS号 : 5451-09-2
货号 : A340721
分子式 : C5H10ClNO3
纯度 : 97%
分子量 : 167.591
MDL号 : MFCD00012869
存储条件：

Pure form Inert atmosphere,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(626.53 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 15 mg/mL(89.5 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方：
生物活性
描述 5-Aminolevulinic acid hydrochloride is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02660645 - Recruiting December 2020 United States, California ... 展开 >> USC/Norris Comprehensive Cancer Center Recruiting Los Angeles, California, United States, 90033 Contact: Ileana Aldana    323-865-0702    ileana.aldana@med.usc.edu    Principal Investigator: Sia Daneshmand, MD          Sub-Investigator: Anne Schuckman, MD          Sub-Investigator: Mihir Desai, MD          Sub-Investigator: Hooman Djaladat, MD          Sub-Investigator: Gerhard Fuchs, MD          Sub-Investigator: Virinder Bhardwaj, MD          VA Palo Alto Health Care System Recruiting Palo Alto, California, United States, 94304 Contact: Dorothy Trivedi       dtrivedi@stanford.edu    Principal Investigator: Joseph Liao, MD          Sub-Investigator: James Crotty, MD          Sub-Investigator: John Leppert, MD          Sub-Investigator: John Lavelle, MD          University of California, San Francisco Recruiting San Francisco, California, United States, 94143 Contact: Sima Porten, MD, MPH    415-885-3695    Sima.Porten@ucsf.edu    Principal Investigator: Sima Porten, MD, MPH          United States, Kansas University of Kansas Medical Center Recruiting Kansas City, Kansas, United States, 66160 Contact: Katie Glavin    913-588-8721    kglavin@kumc.edu    Principal Investigator: John Taylor, MD, MS          Sub-Investigator: Jeffrey Holzbeierlein, MD, FACS          Sub-Investigator: Eugene Lee, MD, FACS          Sub-Investigator: Hadley Wyre, MD          Sub-Investigator: Moben Mirza, MD          United States, Maryland Johns Hopkins Medicine Recruiting Baltimore, Maryland, United States, 21224 Contact: Morgan De Carli       Mdecarl2@jhmi.edu    Principal Investigator: Trinity Bivalacqua, MD, PhD          Sub-Investigator: Phillip Pierorazio, MD          United States, Minnesota University of Minnesota Recruiting Minneapolis, Minnesota, United States, 55455 Contact: Therese Perrier    612-625-3319    perri084@umn.edu    Principal Investigator: Badrinath Konety, MD          Sub-Investigator: Weight Chris, MD          Sub-Investigator: Laureen Hemsley, MD          United States, New York Stony Brook Urology Recruiting Stony Brook, New York, United States, 11794 Contact: Kim Lyktey       Kim.Lyktey@stonybrookmedicine.edu    Principal Investigator: John Fitzgerald, MD          Sub-Investigator: Massimiliano Spaliviero, MD          Sub-Investigator: Wayne Waltzer, MD          United States, Ohio Cincinnati VA Medical Center Not yet recruiting Cincinnati, Ohio, United States, 45220 Contact: Krishnanath Gaitonde, MD          Principal Investigator: Krishnanath Gaitonde, MD          Ohio State University Wexner Medical Center Recruiting Columbus, Ohio, United States, 43210 Contact: Kamal Pohar, MD       kamal.pohar@osumc.edu    Principal Investigator: Kamal Pohar, MD          Sub-Investigator: Megan Merrill, DO          Sub-Investigator: Ahmad Shabsigh, MD          Sub-Investigator: David Sharp, MD          United States, South Carolina Carolina Urology Partners Recruiting West Columbia, South Carolina, United States, 29169 Contact: Nicol Brandon    704-414-2870 ext 2809    Nicol.brandon@carolinaurologypartners.com    Principal Investigator: T. Brian Willard, MD          Sub-Investigator: David Lamb, MD          Sub-Investigator: Scott Sweazy, MD          Sub-Investigator: Keith Birghtbill, MD          Sub-Investigator: Michael Stotzer, MD          United States, Texas UT Southwestern Not yet recruiting Dallas, Texas, United States, 75390 Contact: Yair Lotan, MD    214-645-8787       Principal Investigator: Yair Lotan, MD          Sub-Investigator: Aditya Bagrodia, MD          Sub-Investigator: Vitaly Margulis, MD          Sub-Investigator: Ganesh Raj, MD, PhD          Michael E. DeBakey VA Medical Center Recruiting Houston, Texas, United States, 77030 Contact: Ashley Jones, BS, CCRP    713-791-1414 ext 26694    Ashley.Jones2@bcm.edu    Principal Investigator: Jennifer Taylor, MD, MPH          Sub-Investigator: Jeffrey Jones, MD          Sub-Investigator: Sidney Worsham, MD          United States, West Virginia Charleston Area Medical Center Recruiting Charleston, West Virginia, United States, 25301 Contact: James Tierney, DO    304-388-9944       Principal Investigator: James Tierney, DO          Sub-Investigator: Samuel Deem, DO 收起 <<
NCT02560584 Bladder Cancer Phase 3 Completed - United States, California ... 展开 >> USC Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 United States, Illinois University of Chicago Medical Center Chicago, Illinois, United States, 60637 United States, Iowa University of Iowa Iowa City, Iowa, United States, 52242 United States, Maryland Johns Hopkins University Baltimore, Maryland, United States, 21205 United States, Minnesota University of Minnesota Minneapolis, Minnesota, United States, 55455 United States, New York Montefiore Medical Center Bronx, New York, United States, 10461 NYU Langone Urology Associates New York, New York, United States, 10016 Columbia University Medical Center New York, New York, United States, 10032 United States, North Carolina University of North Carolina, Department of Urology Chapel Hill, North Carolina, United States, 27599 United States, Ohio Ohio State University The James Cancer Hospital Columbus, Ohio, United States, 43210 United States, Oklahoma University of Oklahoma-Stephenson Cancer Center Oklahoma City, Oklahoma, United States, 73104 United States, Pennsylvania Thomas Jefferson University Philadelphia, Pennsylvania, United States, 10197 United States, Tennessee Vanderbilt University Medical Center Nashville, Tennessee, United States, 37232 United States, Texas UT Southwestern Medical Center Dallas, Texas, United States, 75390 MD Anderson Cancer Center Houston, Texas, United States, 77030 Michael E. DeBakey VA Medical Center Houston, Texas, United States, 77030 United States, Wisconsin University of Wisconsin Madison, Wisconsin, United States, 53792 收起 <<
NCT01050309 Pharmacokinetics Phase 1 Completed - Netherlands ... 展开 >> Pra-Eds-Nl Zuidlaren, Netherlands, 9471 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.97mL

1.19mL

0.60mL

29.83mL

5.97mL

2.98mL

59.67mL

11.93mL

5.97mL
参考文献

[1]Karmakar S, Banik NL, et al. 5-Aminolevulinic acid-based photodynamic therapy suppressed survival factors and activated proteases for apoptosis in human glioblastoma U87MG cells. Neurosci Lett. 2007 Mar 30;415(3):242-7.

[2]Onuki J, Chen Y, et al. Mitochondrial and nuclear DNA damage induced by 5-aminolevulinic acid. Arch Biochem Biophys. 2004 Dec 15;432(2):178-87.