Vitexin-4″-O-glucoside (VOG), being a main component in the leaves of Crataegus pinnatifida Bge. Vitexin-4″-O-Glucoside (VOG) can inhibit TPO activity. It is a natural product isolated and purified from the fruit of Crataegus pinnatifida Bge. Additionally, α half-life, β half-life, (a)CL, MRT(0→t ), MRT(0→∞ ), and terminal half-life of VOG in rats showed significant differences between 20 mg/kg and other doses. Thereby, VOG presented a dose-dependent pharmacokinetics in the range of 20-60 mg/kg and non-linear pharmacokinetics at lower dose[3]. In addition, VOR (Vitexin-2"-O-rhamnoside) and VOG caused no cytotoxic effect on hADSCs (human adipose-derived stem cells) at concentrations up to 250 and 480 μm, respectively. Both VOR and VOG contribute to the protection against H2 O2 -mediated oxidative stress damage and could be safely used for a wide range of concentrations[4]. Renal excretion was the dominant path of elimination of VOG for oral and intravenous administration in mice and biliary excretion contributed less[5].
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