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4”-O-Glucosylvitexin

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Chemical Structure| 123063-33-2 同义名 : 4″-O-牡荆素葡萄糖苷 ;Glucosylvitexin
CAS号 : 123063-33-2
货号 : A108675
分子式 : C27H30O16
纯度 : 97%
分子量 : 610.518
MDL号 : N/A
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(409.49 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Vitexin-4″-O-glucoside (VOG), being a main component in the leaves of Crataegus pinnatifida Bge. Vitexin-4″-O-Glucoside (VOG) can inhibit TPO activity. It is a natural product isolated and purified from the fruit of Crataegus pinnatifida Bge. Additionally, α half-life, β half-life, (a)CL, MRT(0→t ), MRT(0→∞ ), and terminal half-life of VOG in rats showed significant differences between 20 mg/kg and other doses. Thereby, VOG presented a dose-dependent pharmacokinetics in the range of 20-60 mg/kg and non-linear pharmacokinetics at lower dose[3]. In addition, VOR (Vitexin-2"-O-rhamnoside) and VOG caused no cytotoxic effect on hADSCs (human adipose-derived stem cells) at concentrations up to 250 and 480 μm, respectively. Both VOR and VOG contribute to the protection against H2 O2 -mediated oxidative stress damage and could be safely used for a wide range of concentrations[4]. Renal excretion was the dominant path of elimination of VOG for oral and intravenous administration in mice and biliary excretion contributed less[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.64mL

0.33mL

0.16mL

8.19mL

1.64mL

0.82mL

16.38mL

3.28mL

1.64mL
参考文献

[1]Wu LZ, Zhang XP, et al. Characterization of aromatic glycosides in the extracts of Trollius species by ultra high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry. J Pharm Biomed Anal. 2013 Mar 5;75:55-63.

[2]Gaitan E, Lindsay RH, et al. Antithyroid and goitrogenic effects of millet: role of C-glycosylflavones. J Clin Endocrinol Metab. 1989 Apr;68(4):707-14.

[3]Ying XX, Wang F, Cheng ZZ, Zhang WJ, Li HB, Du Y, Liu X, Wang SY, Kang TG. Pharmacokinetics of vitexin-4″-O-glucoside in rats after intravenous application. Eur J Drug Metab Pharmacokinet. 2012 Jun;37(2):109-15

[4]Wei W, Ying X, Zhang W, Chen Y, Leng A, Jiang C, Liu J. Effects of vitexin-2"-O-rhamnoside and vitexin-4"-O-glucoside on growth and oxidative stress-induced cell apoptosis of human adipose-derived stem cells. J Pharm Pharmacol. 2014 Jul;66(7):988-97

[5]Cai S, Chen Y, Zhang W, Ying X. Comparative study on the excretion of vitexin-4''-O-glucoside in mice after oral and intravenous administration by using HPLC. Biomed Chromatogr. 2013 Nov;27(11):1375-9