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4-甲基水杨酸 /4-Methylsalicylic acid {[allProObj[0].p_purity_real_show]}

货号:A131260 同义名: 2-羟基-4-甲基苯甲酸 / m-Cresotic acid;2-Hydroxy-4-methylbenzoic acid

4-Methylsalicylic Acid is an inhibitor of the medium chain acyl-CoA synthetase.

4-Methylsalicylic acid 化学结构 CAS号:50-85-1
4-Methylsalicylic acid 化学结构
CAS号:50-85-1
4-Methylsalicylic acid 3D分子结构
CAS号:50-85-1
4-Methylsalicylic acid 化学结构 CAS号:50-85-1
4-Methylsalicylic acid 3D分子结构 CAS号:50-85-1
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4-Methylsalicylic acid 纯度/质量文件 产品仅供科研

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4-Methylsalicylic acid 生物活性

描述 4-methylsalicylic acid, which do not act as substrates for the medium chain acyl-CoA synthetase, were potent as inhibitors. 4-Methylsalicylic acid was more potent than salicylic acid. The inhibitory carboxylic acids were competitive with respect to hexanoic acid. The distance of the hydroxyl group from the carboxylic acid group of the benzene ring influenced the inhibitory activity. The hydroxyl group on the carbon adjacent to the carboxylic acid group was required for inhibitory activity[2]. A series of 1,3,4-oxadiazole derivatives derived from 4-methoxysalicylic acid or 4-methylsalicylic acid (6a-6z) have been first synthesized for their potential immunosuppressive activity. Among them, compound 6z displayed the most potent biological activity against lymph node cells (inhibition=38.76% for lymph node cells and IC(50)=0.31 μM for PI3Kγ)[3].

4-Methylsalicylic acid 参考文献

[2]Kasuya F, Igarashi K, Fukui M. Inhibition of a medium chain acyl-CoA synthetase involved in glycine conjugation by carboxylic acids. Biochem Pharmacol. 1996 Nov 22;52(10):1643-6

[3]Zhang ZM, Zhang XW, Zhao ZZ, Yan R, Xu R, Gong HB, Zhu HL. Synthesis, biological evaluation and molecular docking studies of 1,3,4-oxadiazole derivatives as potential immunosuppressive agents. Bioorg Med Chem. 2012 May 15;20(10):3359-67

4-Methylsalicylic acid 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

6.57mL

1.31mL

0.66mL

32.86mL

6.57mL

3.29mL

65.72mL

13.14mL

6.57mL

4-Methylsalicylic acid 技术信息

CAS号50-85-1
分子式C8H8O3
分子量 152.147
别名 2-羟基-4-甲基苯甲酸 ;m-Cresotic acid;2-Hydroxy-4-methylbenzoic acid;2-Hydroxy-p-toluic acid;m-Cresotinic acid
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature

溶解度
动物实验配方
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