4-Methylesculetin

货号：A214707

4-Methylesculetin是一种口服活性的香豆素衍生物，具有显著的抗氧化和抗炎活性。它通过抑制 myeloperoxidase 活性和非酶促炎症因子（如 TNF-α、IL-1β、COX-2）上调，保护骨吸收，适用于炎症疾病研究。

4-Methylesculetin 化学结构
CAS号：529-84-0

4-Methylesculetin 3D分子结构
CAS号：529-84-0

规格	价格	库存	数量

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4-Methylesculetin 纯度/质量文件产品仅供科研

货号：A214707 标准纯度：产品说明书

批次查询：批次纯度: COA NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • ACS Appl. Nano Mater., 2025. Ambeed. [ A188026 ]; • Eur. J. Clin. Microbiol. Infect. Dis., 2025. Ambeed. [ A151161 ]; • JJC, 2025, 20(Special Issue)): 27-39. Ambeed. [ A713856 ]; • bioRxiv, 2025. Ambeed. [ A538667 , A714873 , A126729 , A126049 , A446054 ]; • Nature Communications, 2025, 16, 1871. Ambeed. [ A508148 ]; 更多 >

4-Methylesculetin 生物活性

描述

4-Methylesculetin is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities. 4-methylesculetin (25 mg/kg) improved microscopic parameters, decreased MPO activity, reduced the colonic levels of IL-6 and counteracted GSH depletion^[1]. 4 ME (4-Methylesculetin) modulated glutathione-related enzymes, mainly increasing glutathione reductase activity. 4 ME acted by different mechanisms to control oxidative stress induced by intestinal damage, controlling the imbalance between myeloperoxidase activity and glutathione production, upregulating the glutathione S-transferase and glutathione reductase activities, preventing the Nrf2 and glutathione gene expression downregulation with consequent glutathione maintenance^[2]. Further, 4-ME significantly ameliorated the upregulated non-enzymatic inflammatory markers like TNF-α, IL-1β, IL-6, COX-2 and PGE2. Besides, 4-ME effectively stabilized the arthritis-induced oxidative stress by restoring the levels of reactive oxygen species, lipid and hydro peroxides and antioxidant enzymes such as superoxide dismutase, catalase and glutathione-S-transferase^[3].

4-Methylesculetin 参考文献

[1]Witaicenis A, de Oliveira ECS, Tanimoto A, Zorzella-Pezavento SFG, de Oliveira SL, Sartori A, Di Stasi LC. 4-methylesculetin, a coumarin derivative, ameliorates dextran sulfate sodium-induced intestinal inflammation. Chem Biol Interact. 2018 Jan 25;280:59-63

[2]Tanimoto A, Witaicenis A, Caruso ÍP, Piva HMR, Araujo GC, Moraes FR, Fossey MC, Cornélio ML, Souza FP, Di Stasi LC. 4-Methylesculetin, a natural coumarin with intestinal anti-inflammatory activity, elicits a glutathione antioxidant response by different mechanisms. Chem Biol Interact. 2020 Jan 5;315:108876

[3]Hemshekhar M, Sunitha K, Thushara RM, Sebastin Santhosh M, Shanmuga Sundaram M, Kemparaju K, Girish KS. Antiarthritic and antiinflammatory propensity of 4-methylesculetin, a coumarin derivative. Biochimie. 2013 Jun;95(6):1326-35

4-Methylesculetin 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

5.20mL

1.04mL

0.52mL

26.02mL

5.20mL

2.60mL

52.04mL

10.41mL

5.20mL

4-Methylesculetin 技术信息

CAS号	529-84-0
分子式	C₁₀H₈O₄
分子量	192.168
smile	CC1=CC(=O)OC2=CC(O)=C(O)C=C12
MDL No.	MFCD00006859

别名
运输	蓝冰
InChI Key	KVOJTUXGYQVLAJ-UHFFFAOYSA-N
Pubchem ID	5319502

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,Room Temperature

溶解方案

细胞实验：

DMSO: 50 mg/mL(260.19 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

动物实验配方

摩尔计算器

计算溶液所需的质量，体积或浓度。 Ambeed 摩尔浓度计算器基于以下方程式：

浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)=质量 (g)

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4-Methylesculetin 实验方案

4-Methylesculetin 技术信息

最近浏览的产品

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摩尔计算器

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总药量计算器

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