货号:A108675
同义名:
4″-O-牡荆素葡萄糖苷
/ Glucosylvitexin
4”-O-Glucosylvitexin可以抑制 TPO 活性。它是从山楂(Crataegus pinnatifida)果实中分离和纯化的天然产物。
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描述 | Vitexin-4″-O-glucoside (VOG), being a main component in the leaves of Crataegus pinnatifida Bge. Vitexin-4″-O-Glucoside (VOG) can inhibit TPO activity. It is a natural product isolated and purified from the fruit of Crataegus pinnatifida Bge. Additionally, α half-life, β half-life, (a)CL, MRT(0→t ), MRT(0→∞ ), and terminal half-life of VOG in rats showed significant differences between 20 mg/kg and other doses. Thereby, VOG presented a dose-dependent pharmacokinetics in the range of 20-60 mg/kg and non-linear pharmacokinetics at lower dose[3]. In addition, VOR (Vitexin-2"-O-rhamnoside) and VOG caused no cytotoxic effect on hADSCs (human adipose-derived stem cells) at concentrations up to 250 and 480 μm, respectively. Both VOR and VOG contribute to the protection against H2 O2 -mediated oxidative stress damage and could be safely used for a wide range of concentrations[4]. Renal excretion was the dominant path of elimination of VOG for oral and intravenous administration in mice and biliary excretion contributed less[5]. |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
1.64mL 0.33mL 0.16mL |
8.19mL 1.64mL 0.82mL |
16.38mL 3.28mL 1.64mL |
CAS号 | 123063-33-2 |
分子式 | C27H30O16 |
分子量 | 610.52 |
SMILES Code | O=C1C=C(C2=CC=C(O)C=C2)OC3=C1C(O)=CC(O)=C3O[C@H]4[C@H](O[C@H]5[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O5)[C@@H](O)[C@H](O)[C@@H](CO)O4 |
MDL No. | N/A |
别名 | 4″-O-牡荆素葡萄糖苷 ;Glucosylvitexin |
运输 | 蓝冰 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Sealed in dry, 2-8°C |
溶解方案 |
DMSO: 250 mg/mL(409.49 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |