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/ 3,3',5-Triiodo-L-thyronine

甲碘安 /3,3',5-Triiodo-L-thyronine {[allProObj[0].p_purity_real_show]}

货号：A267480 同义名： 三碘甲状腺原氨酸 / Triiodothyronine;T3

3,3',5-Triiodo-L-thyronine是一种甲状腺激素激动剂，具有较强的 TRα 和 TRβ 激动作用，Ki 值分别为 2.33 和 2.29 nM，适用于影响代谢等生理过程的研究。

3,3',5-Triiodo-L-thyronine 化学结构 CAS号：6893-02-3
3,3',5-Triiodo-L-thyronine 化学结构
CAS号：6893-02-3
3,3',5-Triiodo-L-thyronine 3D分子结构
CAS号：6893-02-3
3,3',5-Triiodo-L-thyronine 化学结构 CAS号：6893-02-3
3,3',5-Triiodo-L-thyronine 3D分子结构 CAS号：6893-02-3
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3,3',5-Triiodo-L-thyronine 纯度/质量文件 产品仅供科研

货号：A267480 标准纯度： {[allProObj[0].p_purity_real_show]}
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3,3',5-Triiodo-L-thyronine 生物活性

靶点

  • JNK1

    JNK1, Kd:240 nM

  • JNK2

    JNK2, Kd:290 nM

  • JNK3

    JNK3, Kd:66 nM
描述 Liothyronine represents an active thyroid hormone variant. It acts as a powerful agonist for the thyroid hormone receptors TRα and TRβ, exhibiting Ki values of 2.33 nM for both hTRα and hTRβ, respectively[1].[2].[3]. Produced in accordance with GMP guidelines, Liothyronine (Triiodothyronine) (GMP), also known as Liothyronine, functions effectively as a supportive reagent in cell therapy production. It serves as a strong agonist for the thyroid hormone receptors TRα and TRβ with Ki values of 2.33 nM for each, hTRα and hTRβ, respectively[1].
体外研究

In cases where TRβ1 is upregulated, liothyronine (100 nM) enhances the growth of hepatocarcinoma cells[1].

The binding of liothyronine to the human β1 thyroid hormone receptor (hTRβ1) alters its structure, thereby fostering cellular growth, promoting differentiation, and regulating metabolic processes[2].

Liothyronine (GMP) is utilized in the culture mediums essential for generating induced pluripotent stem cells from human keratinocytes[1].

Additionally, it is crucial for the proliferation and self-renewal of limbal stem cells (LSCs)[2].

At a concentration of 4 nM, Liothyronine (GMP) encourages the cardiac differentiation and maturation of embryonic stem cells[3].

Furthermore, Liothyronine (GMP) at 100 Nm over 14 days, enhances the electrophysiological maturation of cardiomyocytes derived from human-induced pluripotent stem cells (hiPSC)[4].

3,3',5-Triiodo-L-thyronine 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02133040 - Active, not recruiting May 10, 2020 Denmark ... 展开 >> Aarhus University Hospital Aarhus, Region Midtjylland, Denmark, 8000 收起 <<
NCT02398344 Stroke Phase 1 Phase 2 Completed - Brazil ... 展开 >> University of Nove de Julho São Paulo, Brazil 收起 <<
NCT02733497 Hyperhidrosis Not Applicable Completed - -

3,3',5-Triiodo-L-thyronine 参考文献

[1]Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94.

[2]Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92.

[3]CY, et al. Triiodothyronine promotes cardiac differentiation and maturation of embryonic stem cells via the classical genomic pathway. Mol Endocrinol. 2010 Sep;24(9):1728-36.

[4]Wang L, et al. Triiodothyronine and dexamethasone alter potassium channel expression and promote electrophysiological maturation of human-induced pluripotent stem cell-derived cardiomyocytes. J Mol Cell Cardiol. 2021 Dec;161:130-138.

3,3',5-Triiodo-L-thyronine 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.54mL

0.31mL

0.15mL

7.68mL

1.54mL

0.77mL

15.36mL

3.07mL

1.54mL

3,3',5-Triiodo-L-thyronine 技术信息

CAS号6893-02-3
分子式C15H12I3NO4
分子量 650.973
别名 三碘甲状腺原氨酸 ;Triiodothyronine;T3;NSC 80203;L-3,3’,5-Triiodothyronine;3,3’,5-Triiodo-L-thyronine;Liothyronine
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place,Inert atmosphere,Room temperature
溶解度

DMSO: 50 mg/mL(76.81 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

1M NaOH: 50 mg/mL(76.81 mM)，配合低频超声助溶
动物实验配方

Tags: Liothyronine (GMP) | 6893-02-3 | Triiodothyronine (GMP) | 3,3',5-Triiodo-L-thyronine (GMP) | T3 (GMP) | TRα/TRβ Agonist (GMP) | Vitamin D Related/Nuclear Receptor | Thyroid Hormone Receptor | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | 3,3',5-Triiodo-L-thyronine 纯度/质量文件 | 3,3',5-Triiodo-L-thyronine 生物活性 | 3,3',5-Triiodo-L-thyronine 临床数据 | 3,3',5-Triiodo-L-thyronine 参考文献 | 3,3',5-Triiodo-L-thyronine 实验方案 | 3,3',5-Triiodo-L-thyronine 技术信息

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