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20(S)-Hydroxycholesterol {[allProObj[0].p_purity_real_show]}

货号：A628488 同义名： 20α-Hydroxycholesterol Ambeed 开学季，买赠积分，赢豪礼

20(S)-Hydroxycholesterol is an allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein. It activates Hedgehog (Hh) signaling with EC50 value of ~ 3μM for induction of Hh reporter gene transcription in NIH 3T3 cells.

20(S)-Hydroxycholesterol 化学结构 CAS号：516-72-3
20(S)-Hydroxycholesterol 化学结构
CAS号：516-72-3
20(S)-Hydroxycholesterol 3D分子结构
CAS号：516-72-3
20(S)-Hydroxycholesterol 化学结构 CAS号：516-72-3
20(S)-Hydroxycholesterol 3D分子结构 CAS号：516-72-3
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20(S)-Hydroxycholesterol 纯度/质量文件 产品仅供科研

货号：A628488 标准纯度： {[allProObj[0].p_purity_real_show]}
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20(S)-Hydroxycholesterol 生物活性

描述 20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC50 of 3 μM in a gene transcription reporter assay using NIH3T3 cells[1]. Like human and mouse MSCs, 20S oxysterol expressed pro-osteogenic, pro-myogenic, and anti-adipogenic differentiation potential in cBMSCs. Moreover, 20(S)-Hydroxycholesterol induced markers of osteogenic genes and myogenic regulatory factors when exposed to cBMSCs treated with their specific medium[2]. Treatment of M2-10B4 cells with the osteogenic oxysterol 20S completely inhibited adipocyte formation induced by troglitazone after 10 days. Furthermore, 20S and Shh greatly inhibited PPARgamma2 promoter activity induced by CCAAT/enhancer-binding protein alpha overexpression[3].

20(S)-Hydroxycholesterol 参考文献

[1]Nedelcu D, Liu J, Xu Y, Jao C, Salic A. Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling. Nat Chem Biol. 2013 Sep;9(9):557-64

[2]Adhikari R, Chen C, Kim WK. Effect of 20(S)-Hydroxycholesterol on Multilineage Differentiation of Mesenchymal Stem Cells Isolated from Compact Bones in Chicken. Genes (Basel). 2020 Nov 17;11(11):1360

[3]Kim WK, Meliton V, Amantea CM, Hahn TJ, Parhami F. 20(S)-hydroxycholesterol inhibits PPARgamma expression and adipogenic differentiation of bone marrow stromal cells through a hedgehog-dependent mechanism. J Bone Miner Res. 2007 Nov;22(11):1711-9

20(S)-Hydroxycholesterol 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.48mL

0.50mL

0.25mL

12.42mL

2.48mL

1.24mL

24.84mL

4.97mL

2.48mL

20(S)-Hydroxycholesterol 技术信息

CAS号516-72-3
分子式C27H46O2
分子量 402.653
别名 20α-Hydroxycholesterol
运输蓝冰
存储条件

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 12 mg/mL(29.8 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: 20(S)-Hydroxycholesterol | 516-72-3 | 20α-Hydroxycholesterol | Smo | Smo Activator | Stem Cell/Wnt | Metabolic Enzyme/Protease | Smo | Endogenous Metabolite | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | 20(S)-Hydroxycholesterol 纯度/质量文件 | 20(S)-Hydroxycholesterol 生物活性 | 20(S)-Hydroxycholesterol 参考文献 | 20(S)-Hydroxycholesterol 实验方案 | 20(S)-Hydroxycholesterol 技术信息

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