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2-脱氧-D-葡萄糖 /2-Deoxy-D-glucose {[allProObj[0].p_purity_real_show]}

货号:A104420 同义名: D-2-脱氧葡萄糖 / 2-DG;2-Deoxy-D-arabino-hexose Ambeed 开学季,买赠积分,赢豪礼

2-Deoxy-D-glucose 是一种葡萄糖类似物,通过作用于己糖激酶 (hexokinase) 来抑制糖酵解 (glycolysis) 的葡萄糖代谢抑制剂。

2-Deoxy-D-glucose 化学结构 CAS号:154-17-6
2-Deoxy-D-glucose 化学结构
CAS号:154-17-6
2-Deoxy-D-glucose 3D分子结构
CAS号:154-17-6
2-Deoxy-D-glucose 化学结构 CAS号:154-17-6
2-Deoxy-D-glucose 3D分子结构 CAS号:154-17-6
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2-Deoxy-D-glucose 纯度/质量文件 产品仅供科研

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2-Deoxy-D-glucose 生物活性

描述 2-Deoxy-D-glucose (2DG), a glucose analog, targets glucose metabolism to deplete cancer cells of energy. In addition, 2DG increases oxidative stress, inhibits N-linked glycosylation, and induces autophagy. It can efficiently slow cell growth and potently facilitate apoptosis in specific cancer cells[3]. Acting as a d-glucose mimic, 2-DG inhibits glycolysis due to formation and intracellular accumulation of 2-deoxy-d-glucose-6-phosphate (2-DG6P), inhibiting the function of hexokinase and glucose-6-phosphate isomerase, and inducing cell death[4]. The combination of 2-DG and HCPT (hydroxycamptothecin) can synergistically induce the apoptosis of breast cancer cells, which may be caused by inhibiting the energy generation of tumor cells, inhibiting the phosphorylation of Akt protein and enhancing the activity of caspase-3 protein[5].

2-Deoxy-D-glucose 参考文献

[1]Yao J, Chen S, et al. 2-Deoxy-D-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease. PLoS One. 2011;6(7):e21788.

[2]Zhong D, Xiong L, et al. The glycolytic inhibitor 2-deoxyglucose activates multiple prosurvival pathways through IGF1R. J Biol Chem. 2009 Aug 28;284(35):23225-33.

[3]Zhang D, Li J, Wang F, Hu J, Wang S, Sun Y. 2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy. Cancer Lett. 2014 Dec 28;355(2):176-83

[4]Pajak B, Siwiak E, Sołtyka M, Priebe A, Zieliński R, Fokt I, Ziemniak M, Jaśkiewicz A, Borowski R, Domoradzki T, Priebe W. 2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents. Int J Mol Sci. 2019 Dec 29;21(1):234

[5]Ge XM, Liu YM, Zhang P, Sun XJ, Zhen YN, Li JH, Liu H. [Synergistic Effect of 2-deoxy-D-glucose Combined with Hydroxycamptothecin on Apoptosis of Breast Cancer Cells]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2019 Jul;50(4):527-532. Chinese

2-Deoxy-D-glucose 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

6.09mL

1.22mL

0.61mL

30.46mL

6.09mL

3.05mL

60.92mL

12.18mL

6.09mL

2-Deoxy-D-glucose 技术信息

CAS号154-17-6
分子式C6H12O5
分子量 164.15
别名 D-2-脱氧葡萄糖 ;2-DG;2-Deoxy-D-arabino-hexose;Ba 2758;NSC 15193;2-deoxyglucose;D-Arabino-2-deoxyhexose
运输蓝冰
存储条件

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

H2O: 20 mg/mL(121.84 mM)

动物实验配方
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