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2-Deoxy-D-glucose

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Chemical Structure| 154-17-6 同义名 : D-2-脱氧葡萄糖 ;2-DG;2-Deoxy-D-arabino-hexose;Ba 2758;NSC 15193;2-deoxyglucose;D-Arabino-2-deoxyhexose
CAS号 : 154-17-6
货号 : A104420
分子式 : C6H12O5
纯度 : 98%
分子量 : 164.15
MDL号 : MFCD00151328
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 20 mg/mL(121.84 mM)
动物实验配方：
生物活性
描述 2-Deoxy-D-glucose (2DG), a glucose analog, targets glucose metabolism to deplete cancer cells of energy. In addition, 2DG increases oxidative stress, inhibits N-linked glycosylation, and induces autophagy. It can efficiently slow cell growth and potently facilitate apoptosis in specific cancer cells[3]. Acting as a d-glucose mimic, 2-DG inhibits glycolysis due to formation and intracellular accumulation of 2-deoxy-d-glucose-6-phosphate (2-DG6P), inhibiting the function of hexokinase and glucose-6-phosphate isomerase, and inducing cell death[4]. The combination of 2-DG and HCPT (hydroxycamptothecin) can synergistically induce the apoptosis of breast cancer cells, which may be caused by inhibiting the energy generation of tumor cells, inhibiting the phosphorylation of Akt protein and enhancing the activity of caspase-3 protein[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.09mL

1.22mL

0.61mL

30.46mL

6.09mL

3.05mL

60.92mL

12.18mL

6.09mL
参考文献

[1]Yao J, Chen S, et al. 2-Deoxy-D-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease. PLoS One. 2011;6(7):e21788.

[2]Zhong D, Xiong L, et al. The glycolytic inhibitor 2-deoxyglucose activates multiple prosurvival pathways through IGF1R. J Biol Chem. 2009 Aug 28;284(35):23225-33.

[3]Zhang D, Li J, Wang F, Hu J, Wang S, Sun Y. 2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy. Cancer Lett. 2014 Dec 28;355(2):176-83

[4]Pajak B, Siwiak E, Sołtyka M, Priebe A, Zieliński R, Fokt I, Ziemniak M, Jaśkiewicz A, Borowski R, Domoradzki T, Priebe W. 2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents. Int J Mol Sci. 2019 Dec 29;21(1):234

[5]Ge XM, Liu YM, Zhang P, Sun XJ, Zhen YN, Li JH, Liu H. [Synergistic Effect of 2-deoxy-D-glucose Combined with Hydroxycamptothecin on Apoptosis of Breast Cancer Cells]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2019 Jul;50(4):527-532. Chinese