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18β-Glycyrrhetinic acid

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Chemical Structure| 471-53-4 同义名 : 18β-甘草次酸;甘草次酸;甘草次酸(β型） ;Arthrodont;Enoxolone;BRN 2229654;Glycyrrhetic acid;STX 352;PO 12;NSC 35347;GM 1658;α-Glycyrrhetinic Acid​;Biosone;Glycyrrhetin
CAS号 : 471-53-4
货号 : A480562
分子式 : C30H46O4
纯度 : 99%
分子量 : 470.684
MDL号 : MFCD00003706
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(254.95 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

IP 2% DMSO+2% Tween80+40% PEG300+water 5 mg/mL clear

PO 0.5% CMC-Na 60 mg/mL suspension

生物活性
靶点

  • Dehydrogenase
描述 Enoxolone is Gap junction inhibitor and a bioactive compound in licorice that exhibits potential anti-cancer, anti-inflammatory, and anti-microbial activities.In vitro， this Enoxolone derivative did not cause cell death, but significantly enhanced the proliferation of dermal fibroblasts and HaCaT keratinocytes. A scratch wound healing assay revealed that the Enoxolone derivative promoted the migration of fibroblasts[3]. In vivo，histological data also indicated Enoxolone has no effects on inflammatory joint destruction[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.12mL

0.42mL

0.21mL

10.62mL

2.12mL

1.06mL

21.25mL

4.25mL

2.12mL
参考文献

[1]Zhu J, Chen M, et al. Glycyrrhetinic acid induces G1‑phase cell cycle arrest in human non‑small cell lung cancer cells through endoplasmic reticulum stress pathway. Int J Oncol. 2015 Mar;46(3):981-8.

[2]Pirzadeh S, Fakhari S, et al. Glycyrrhetinic Acid Induces Apoptosis in Leukemic HL60 Cells Through Upregulating of CD95/ CD178. Int J Mol Cell Med. 2014 Fall;3(4):272-8.

[3]Hung CF, Hsiao CY, Hsieh WH, Li HJ, Tsai YJ, Lin CN, Chang HH, Wu NL. 18ß-glycyrrhetinic acid derivative promotes proliferation, migration and aquaporin-3 expression in human dermal fibroblasts. PLoS One. 2017 Aug 16;12(8):e0182981. doi: 10.1371/journal.pone.0182981. PMID: 28813533; PMCID: PMC5558956.

[4]Puchner A, Hayer S, Niederreiter B, Hladik A, Blueml S, Bonelli M, Scheinecker C, Smolen J, Redlich K. Effects of 18β-Glycyrrhetinic acid in hTNFtg mice - a model of rheumatoid arthritis. Wien Klin Wochenschr. 2012 Mar;124(5-6):170-6. doi: 10.1007/s00508-011-0103-z. Epub 2012 Jan 3. PMID: 22210441.