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17α-羟孕酮 /17α-Hydroxyprogesterone {[allProObj[0].p_purity_real_show]}

货号:A939446 同义名: 羟孕酮 / 17-Hydroxyprogesterone;17-OHP

17α-Hydroxyprogesterone是一种内源性孕激素,作为类固醇激素(如糖皮质激素、雄激素、雌激素)生物合成的中间体。

17α-Hydroxyprogesterone 化学结构 CAS号:68-96-2
17α-Hydroxyprogesterone 化学结构
CAS号:68-96-2
17α-Hydroxyprogesterone 3D分子结构
CAS号:68-96-2
17α-Hydroxyprogesterone 化学结构 CAS号:68-96-2
17α-Hydroxyprogesterone 3D分子结构 CAS号:68-96-2
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17α-Hydroxyprogesterone 纯度/质量文件 产品仅供科研

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17α-Hydroxyprogesterone 生物活性

描述 17-Hydroxyprogesterone (17-OHP) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens[3]. 17OHP-C has been demonstrated to be an effective method for prevention of recurrent preterm birth[4]. 20a-dihydroprogesterone and 17a-hydroxyprogesterone, may well reflect the actual gonadotrophic stimulation in a particular individual at the time of testicular biopsy[5].

17α-Hydroxyprogesterone 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03505541 - Recruiting September 1, 2019 United States, Minnesota ... 展开 >> Fairview Hospital Recruiting Minneapolis, Minnesota, United States, 55344 Contact: Hiba Mustafa, MD    612-273-4040    musta062@umn.edu 收起 <<
NCT01501890 Threatened Abortion ... 展开 >> Pre-Eclampsia Abruptio Placentae Fetal Growth Retardation Premature Birth 收起 << Not Applicable Withdrawn(never started) September 2014 Israel ... 展开 >> Soroka University Medical Center Beer Sheva, Israel 收起 <<

17α-Hydroxyprogesterone 参考文献

[1]Fatihah SN, Safiah J, et al. Effect of 17α-hydroxyprogesterone and 17α-hydroxypregnenolone on sperm quality and sperm quantity in male mud spiny lobster (Panulirus polyphagus). Pak J Biol Sci. 2014 Oct;17(10):1124-9.

[2]Attardi BJ, Zeleznik A, et al. Comparison of progesterone and glucocorticoid receptor binding and stimulation of gene expression by progesterone, 17-alpha hydroxyprogesterone caproate, and related progestins. Am J Obstet Gynecol. 2007 Dec;197(6):599.e1-7.

[3]Reed-Kane D Pharmd Fiacp Faca Fc, Kirschbaum K Phd. Prevention of preterm delivery with compounded 17a-hydroxyprogesterone caproate. Int J Pharm Compd. 2006 May-Jun;10(3):165-71

[4]Hoppe K, Kramer RD, Ha B, Rohan A, Aeschbach C, Ehrenthal DB. Progesterone Supplementation for the Prevention of Preterm Birth: Provider Practice in Wisconsin. WMJ. 2019 Oct;118(3):126-131

[5]Berg AA, Kjessler B. In vitro-metabolism of 3H-progesterone in human testicular tissue: IV Before and after long-term gonadotrophin treatment; including one 47, XYY-male. Acta Endocrinol Suppl (Copenh). 1976;207:49-59

17α-Hydroxyprogesterone 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.03mL

0.61mL

0.30mL

15.13mL

3.03mL

1.51mL

30.26mL

6.05mL

3.03mL

17α-Hydroxyprogesterone 技术信息

CAS号68-96-2
分子式C21H30O3
分子量 330.46
别名 羟孕酮 ;17-Hydroxyprogesterone;17-OHP;Hydroxyprogesterone;17A-Hydroxyprogesterone;NSC 15468
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,Room Temperature

溶解方案

DMSO: 50 mg/mL(151.3 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
方案二
动物实验配方
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