17α-Hydroxyprogesterone

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Chemical Structure| 68-96-2 同义名 : 羟孕酮 ;17-Hydroxyprogesterone;17-OHP;Hydroxyprogesterone;17A-Hydroxyprogesterone;NSC 15468
CAS号 : 68-96-2
货号 : A939446
分子式 : C21H30O3
纯度 : 98%
分子量 : 330.46
MDL号 : MFCD00003659
存储条件:

Pure form Sealed in dry,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 50 mg/mL(151.3 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 17-Hydroxyprogesterone (17-OHP) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens[3]. 17OHP-C has been demonstrated to be an effective method for prevention of recurrent preterm birth[4]. 20a-dihydroprogesterone and 17a-hydroxyprogesterone, may well reflect the actual gonadotrophic stimulation in a particular individual at the time of testicular biopsy[5].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03505541 - Recruiting September 1, 2019 United States, Minnesota ... 展开 >> Fairview Hospital Recruiting Minneapolis, Minnesota, United States, 55344 Contact: Hiba Mustafa, MD    612-273-4040    musta062@umn.edu 收起 <<
NCT01501890 Threatened Abortion ... 展开 >> Pre-Eclampsia Abruptio Placentae Fetal Growth Retardation Premature Birth 收起 << Not Applicable Withdrawn(never started) September 2014 Israel ... 展开 >> Soroka University Medical Center Beer Sheva, Israel 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.03mL

0.61mL

0.30mL

15.13mL

3.03mL

1.51mL

30.26mL

6.05mL

3.03mL

参考文献

[1]Fatihah SN, Safiah J, et al. Effect of 17α-hydroxyprogesterone and 17α-hydroxypregnenolone on sperm quality and sperm quantity in male mud spiny lobster (Panulirus polyphagus). Pak J Biol Sci. 2014 Oct;17(10):1124-9.

[2]Attardi BJ, Zeleznik A, et al. Comparison of progesterone and glucocorticoid receptor binding and stimulation of gene expression by progesterone, 17-alpha hydroxyprogesterone caproate, and related progestins. Am J Obstet Gynecol. 2007 Dec;197(6):599.e1-7.

[3]Reed-Kane D Pharmd Fiacp Faca Fc, Kirschbaum K Phd. Prevention of preterm delivery with compounded 17a-hydroxyprogesterone caproate. Int J Pharm Compd. 2006 May-Jun;10(3):165-71

[4]Hoppe K, Kramer RD, Ha B, Rohan A, Aeschbach C, Ehrenthal DB. Progesterone Supplementation for the Prevention of Preterm Birth: Provider Practice in Wisconsin. WMJ. 2019 Oct;118(3):126-131

[5]Berg AA, Kjessler B. In vitro-metabolism of 3H-progesterone in human testicular tissue: IV Before and after long-term gonadotrophin treatment; including one 47, XYY-male. Acta Endocrinol Suppl (Copenh). 1976;207:49-59