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10-去乙酰紫杉醇 /10-Deacetyltaxol {[allProObj[0].p_purity_real_show]}

货号:A710576 同义名: 去乙酰紫衫醇 / 10-Deacetylpaclitaxel;Deacetyltaxol

10-Deacetyltaxol是一种从红豆杉中提取的紫杉醇衍生物,能够促进微管蛋白的聚合并在人类脑胶质细胞和神经母细胞瘤细胞系中表现出细胞毒性。

10-Deacetyltaxol 化学结构 CAS号:78432-77-6
10-Deacetyltaxol 化学结构
CAS号:78432-77-6
10-Deacetyltaxol 3D分子结构
CAS号:78432-77-6
10-Deacetyltaxol 化学结构 CAS号:78432-77-6
10-Deacetyltaxol 3D分子结构 CAS号:78432-77-6
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10-Deacetyltaxol 纯度/质量文件 产品仅供科研

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10-Deacetyltaxol 生物活性

描述 Deacetyltaxol (10-Deacetyltaxol) is a taxane derivative isolated from Taxus wallichiana Zucc[2]. 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro. 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines[3]. The wood of Taxus yunnanensis (Taxaceae) showed growth inhibitory activities against human cancer cell lines, such as cervical HeLa adenocarcinoma. Taxane-type diterpenes, such as 10-deacetylcephalomannine and 10-deacetyltaxol, were found to be present in amounts consistent with the growth inhibitory activity[4].

10-Deacetyltaxol 参考文献

[1]Helson L. Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines. Int J Oncol. 1993 Feb;2(2):297-9.

[2]McLaughlin JL, Miller RW, Powell RG, Smith CR Jr. 19-Hydroxybaccatin III, 10-deacetylcephalomannine, and 10-deacetyltaxol: new antitumor taxanes from Taxus wallichiana. J Nat Prod. 1981 May-Jun;44(3):312-9

[3]Helson L. Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines. Int J Oncol. 1993 Feb;2(2):297-9

[4]Ueda JY, Awale S, Tezuka Y, Shimamura E, Hirai K, Nobukawa T, Sato A, Kadota S. Growth inhibitory activity of wood of Taxus yunnanensis and its liquid chromatography Fourier-transform mass spectrometry analysis. Planta Med. 2006 Oct;72(13):1241-4

10-Deacetyltaxol 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.23mL

0.25mL

0.12mL

6.16mL

1.23mL

0.62mL

12.32mL

2.46mL

1.23mL

10-Deacetyltaxol 技术信息

CAS号78432-77-6
分子式C45H49NO13
分子量 811.87
别名 去乙酰紫衫醇 ;10-Deacetylpaclitaxel;Deacetyltaxol;10-DAP
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,2-8°C

溶解度

DMSO: 120 mg/mL(147.81 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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