货号:A710576 同义名: 去乙酰紫衫醇 / 10-Deacetylpaclitaxel;Deacetyltaxol
10-Deacetyltaxol是一种从红豆杉中提取的紫杉醇衍生物,能够促进微管蛋白的聚合并在人类脑胶质细胞和神经母细胞瘤细胞系中表现出细胞毒性。
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描述 | Deacetyltaxol (10-Deacetyltaxol) is a taxane derivative isolated from Taxus wallichiana Zucc[2]. 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro. 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines[3]. The wood of Taxus yunnanensis (Taxaceae) showed growth inhibitory activities against human cancer cell lines, such as cervical HeLa adenocarcinoma. Taxane-type diterpenes, such as 10-deacetylcephalomannine and 10-deacetyltaxol, were found to be present in amounts consistent with the growth inhibitory activity[4]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
1.23mL 0.25mL 0.12mL |
6.16mL 1.23mL 0.62mL |
12.32mL 2.46mL 1.23mL |
CAS号 | 78432-77-6 |
分子式 | C45H49NO13 |
分子量 | 811.87 |
别名 | 去乙酰紫衫醇 ;10-Deacetylpaclitaxel;Deacetyltaxol;10-DAP |
运输 | 蓝冰 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Sealed in dry,2-8°C |
溶解度 |
DMSO: 120 mg/mL(147.81 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |