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1-Deoxynojirimycin hydrochloride {[allProObj[0].p_purity_real_show]}

货号：A198597

1-Deoxynojirimycin hydrochloride是一种口服有效的 α-葡萄糖苷酶抑制剂，能够抑制餐后血糖，预防糖尿病，且具有降血糖、减肥和抗病毒的作用。

1-Deoxynojirimycin hydrochloride 化学结构 CAS号：73285-50-4
1-Deoxynojirimycin hydrochloride 化学结构
CAS号：73285-50-4
1-Deoxynojirimycin hydrochloride 3D分子结构
CAS号：73285-50-4
1-Deoxynojirimycin hydrochloride 化学结构 CAS号：73285-50-4
1-Deoxynojirimycin hydrochloride 3D分子结构 CAS号：73285-50-4
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1-Deoxynojirimycin hydrochloride 纯度/质量文件 产品仅供科研

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1-Deoxynojirimycin hydrochloride 生物活性

描述 Deoxynojirimycin (1-Deoxynojirimycin) HCl, a natural product isolated and purified from the root barks of Morus alba L., shows inhibitory activity against α-glucosidases, inhibitors of α-glucosidase are promising candidates for the development of antitype II diabetics and anti-AIDS drugs[3]. Hypoglycemic agent DNJ could suppress the adipogenesis during the differentiation of white preadipocytes, and promote the switch of white preadipocytes to beige adipocytes via activating AMPK[4]. DNJ can increase hepatic insulin sensitivity via strengthening of the insulin-stimulated PKB/GSK-3β signal pathway and by modulating glucose metabolic enzymes in db/db mice. Moreover, DNJ also can improve lipid homeostasis and attenuate hepatic steatosis in db/db mice[5]. Caloric restriction and 1-deoxynojirimycin inhibit growth of colorectal cancer by inducing apoptosis in an induced cancer model in mice[6].

1-Deoxynojirimycin hydrochloride 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01380743 Pompe Disease Phase 2 Completed - United States, Arizona ... 展开 >> Phoenix, Arizona, United States, 85018 Scottsdale, Arizona, United States, 85258 United States, California Orange, California, United States, 92868 United States, Florida Gainesville, Florida, United States, 32610 United States, Georgia Decatur, Georgia, United States, 30033 United States, Kansas Kansas City, Kansas, United States, 66160 United States, Montana Great Falls, Montana, United States, 59405 United States, North Carolina Durham, North Carolina, United States, 27710 United States, Ohio Cincinnati, Ohio, United States, 45299 United States, Oregon Portland, Oregon, United States, 97239 United States, Virginia Springfield, Virginia, United States, 22152 Canada, Ontario Hamilton, Ontario, Canada, L8N 3Z5 France Paris, France, 75013 United Kingdom London, Queen Square, United Kingdom, WC1N 3BG Salford, United Kingdom, M68 HD 收起 <<
NCT01853852 Fabry Disease Phase 1 Completed - Australia, New South Wales ... 展开 >> GSK Investigational Site Randwick, New South Wales, Australia, 2031 收起 <<
NCT02194985 Fabry Disease Phase 3 Active, not recruiting October 2019 -

1-Deoxynojirimycin hydrochloride 参考文献

[1]Warfield KL, Plummer EM, et al. Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4. Antiviral Res. 2016 May;129:93-8.

[2]Ma CM, Hattori M, et al. Chlorogenic acid derivatives with alkyl chains of different lengths and orientations: potent alpha-glucosidase inhibitors. J Med Chem. 2008 Oct 9;51(19):6188-94.

[3]Hong KQ, Fu XM, Yin H, Li ST, Chen T, Wang ZW. Advances in the Extraction, Purification and Detection of the Natural Product 1-Deoxynojirimycin. Crit Rev Anal Chem. 2021;51(3):246-257

[4]Li AN, Chen JJ, Li QQ, Zeng GY, Chen QY, Chen JL, Liao ZM, Jin P, Wang KS, Yang ZC. Alpha-glucosidase inhibitor 1-Deoxynojirimycin promotes beige remodeling of 3T3-L1 preadipocytes via activating AMPK. Biochem Biophys Res Commun. 2019 Feb 19;509(4):1001-1007

[5]Liu Q, Li X, Li C, Zheng Y, Wang F, Li H, Peng G. 1-Deoxynojirimycin Alleviates Liver Injury and Improves Hepatic Glucose Metabolism in db/db Mice. Molecules. 2016 Feb 27;21(3):279

[6]E S, Yamamoto K, Sakamoto Y, Mizowaki Y, Iwagaki Y, Kimura T, Nakagawa K, Miyazawa T, Tsuduki T. Intake of mulberry 1-deoxynojirimycin prevents colorectal cancer in mice. J Clin Biochem Nutr. 2017 Jul;61(1):47-52

1-Deoxynojirimycin hydrochloride 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

5.01mL

1.00mL

0.50mL

25.05mL

5.01mL

2.50mL

50.09mL

10.02mL

5.01mL

1-Deoxynojirimycin hydrochloride 技术信息

CAS号73285-50-4
分子式C6H14ClNO4
分子量 199.633
别名
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere,2-8°C
溶解方案

H2O: 250 mg/mL(1252.3 mM)，配合低频超声助溶
动物实验配方

Tags: 1-Deoxynojirimycin hydrochloride | Glucosidase | AmBeed-信号通路专用抑制剂 | 1-Deoxynojirimycin hydrochloride 纯度/质量文件 | 1-Deoxynojirimycin hydrochloride 生物活性 | 1-Deoxynojirimycin hydrochloride 临床数据 | 1-Deoxynojirimycin hydrochloride 参考文献 | 1-Deoxynojirimycin hydrochloride 实验方案 | 1-Deoxynojirimycin hydrochloride 技术信息

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