1-(2,3-Dichlorophenyl)ethanamine hydrochloride
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货号：A254512
High affinity inhibitor of phenylethanolamine-N-methyltransferase (PNMT) (Ki = 0.09 μM in vitro). Suppresses the release of growth hormone in an in vivo rat model.
1-(2,3-Dichlorophenyl)ethanamine hydrochloride 化学结构
1-(2,3-Dichlorophenyl)ethanamine hydrochloride 3D分子结构
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1-(2,3-Dichlorophenyl)ethanamine hydrochloride 纯度/质量文件 产品仅供科研
货号：A254512
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1-(2,3-Dichlorophenyl)ethanamine hydrochloride 质控信息
1-(2,3-Dichlorophenyl)ethanamine hydrochloride 生物活性
描述
Phenylethanolamine-N-methyltransferase (PNMT) is an enzyme that catalyzes the final step of the biosynthesis of epinephrine from norepinephrine. LY 78335 is a PNMT inhibitor with a K i value of 0.09μM in vitro . The half-life of LY 78335 in rat adrenal glands after injection of a dose of 0.2mmol/kg was 3.4 hours. Treatment of rats with 0.2mmol/kg LY 78335 1 hour before forced exercise led to a significant reduction in the epinephrine level compared with the saline-treated controls[1] [2]
1-(2,3-Dichlorophenyl)ethanamine hydrochloride 参考文献
[1] References are publications that support the biological activity of the product.
Fuller
et al
(1973)
Inhibition of phenylethanolamine N-methyltransferase by benzylamines. 2. In vitro and in vivo studies with 2,3-dichloro-α-methylbenzylamine.
J.Med.Chem. 16
106 PMID: 4683104
Terry
et al
(1982)
Regulation of episodic GH secretion by the central epinephrine system.
J.Clin.Invest. 69
104 PMID: 7054231
Grunewald
et al
(1988)
Synthesis and evaluation of 3-substituted analogues of 1,2,3,4-tetrahydroisoquinoline as inhibitors of phenylethanolamine N-methyltransferase.
J.Med.Chem. 31
824 PMID: 3351861
If you know of a relevant reference for LY 78335, please let us know.
[2] Fuller RW, Roush BW, Snoddy HD, Molloy BB. Inhibition of phenylethanolamine N-methyltransferase by benzylamines. 2. In vitro and in vivo studies with 2,3-dichloro-methylbenzylamine. J Med Chem. 1973 Feb;16(2):106-9.
[3] Durcan MJ, Lister RG, Linnoila M. Behavioral effects of the inhibitors of phenylethanolamine-N-methyltransferase, LY 78335 and LY 134046, and their interactions with ethanol. Psychopharmacology (Berl). 1990;101(2):196-202.
1-(2,3-Dichlorophenyl)ethanamine hydrochloride 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
4.41mL
0.88mL
0.44mL
22.07mL
4.41mL
2.21mL
44.14mL
8.83mL
4.41mL
1-(2,3-Dichlorophenyl)ethanamine hydrochloride 技术信息
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