ETC-159 is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.

LGK974 (WNT974) 是一种口服可用和特异性的 Porcupine (PORCN) 抑制剂，IC50 为 0.1 nM。

IWP-O1 is highly potent Porcn inhibitor with EC50 value of 80 pM.

IWP L6 is a Porcn inhibitor with EC50 of 0.5 nM.

Wnt-C59 是一种 Wnt 信号通路抑制剂，对 Porcupine 的 IC50 值为 74 nM。Wnt-C59 具有抗肿瘤作用，可用于 Wnt 相关癌症和再生医学的研究。

Porcupine-IN-1 is potent porcupine inhibitor with an IC50 of 0.5±0.2 nM.

GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.

IWP 12 is a potent inhibitor of Porcupine (PORCN) with IC50 of 15 nM.