COH34是一种有效且特异性的聚(ADP-核糖)糖水解酶 (PARG) 抑制剂，IC₅₀为0.37 nM。COH34 通过与PARG催化结构域结合，延长DNA损伤部位的PARylation，促进DNA修复因子的聚集，适用于DNA损伤修复相关研究。

PARG-IN-4是一种口服活性和细胞渗透性的 PARG 抑制剂，能够有效抑制小鼠模型中的肿瘤生长，适用于癌症研究。

PDD00017273 is a potent and selective inhibitor of Poly(ADP-ribose) glycohydrolase (PARG), with an IC50 of 26 nM, and a KD of 1.45 nM. It catalyses hydrolysis of the O-glycosidic linkages of ADP-ribose polymers, reversing the effects of poly(ADP-ribose) polymerases (PARPs). PDD 00017273 suppresses the ZR-75-1 cells carring BRCA1 and BRCA2 wild type, and exhibits less potent activities against MDA-MB-436 cells carry the 5396 + 1G>A mutation in BRCA1. It is used for specific killing of cells defective in certain homologous recombination (HR) proteins such as breast cancer gene 1/2 (BRCA1/2).